Correlation Between Serum Androgen Levels And Acute Aortic Dissection

Objective:To study the relationship between serum androgen levels and acute aortic dissection.Methods:From February 2016 to July 2018,a total of 201 male participants met the inclusion criteria including 101 acute aortic dissection patients [group AAD,mean age(57.15 ± 10.35)years],100 non-acute aortic dissection patients [group Control,mean age(58.99 ± 9.72)years].Exclusion criteria :(1)taking drugs affecting androgen level within3 months;(2)hypothalamic and pituitary diseases,autoimmune disease,severe hepatic and renal dysfunction,prostate cancer and other diseases that affect androgen levels;(3)patients with aortic dissection caused by diseases of the immune system,marfan syndrome,inflammation,trauma and valve disease;(4)Other vascular diseases.Multivariate logistic regression was used to analyze the relationship between serum androgen levels and acute aortic dissection after adjusting for age,BMI,smoking and other factors.Results:The serum levels of total testosterone and free testosterone in AAD group were lower than those in the Control group(7.58 ± 3.71 vs 10.71 ± 4.30,P<0.001;36.35 ±19.94 vs 58.75 ± 21.24,P<0.001).High levels of total and free testosterone reduce the risk of AAD(OR=0.81,95%CI=0.74,0.88,P<0.001;OR=0.95,95%CI=0.93,0.97,P<0.001).Multivariate logistic regression analysis showed that after adjusting for related risk factors,the risk of AAD at high free testosterone(?50%)was 0.213 times then the lower(OR=0.213,95%CI=0.076,0.595,P<0.05).Conclusion:The decrease of serum free testosterone in male was closely related to the occurrence of AAD.