The Association Between Autophagy Related Gene Polymorphism And Abdominal Aortic Aneurysm

Objective: Development of many human diseases and autophagy is closely with the occurrence.The role of autophagy in the occurrence and development of abdominal aortic aneurysms has been the focus of research in recent years.The association between autophagy related gene polymorphisms and the development of abdominal aortic aneurysms has not been reported.In this study,we collected blood samples from Northeast China and studied the association between autophagy related gene polymorphisms and abdominal aortic aneurysms.Methods: A total of 538 subjects,including 219 patients with abdominal aortic aneurysms and 219 controls,were included in this study.Case data and blood samples were collected,respectively,The rs807185,rs2241880,rs2241880 and rs573775 of ATG16 LA and rs573775 of ATG5 gene were detected by PCR and DNA was extracted from whole blood and ATG4 A gene,To analyze the relationship between the single nucleotide polymorphisms at these sites and abdominal aortic aneurysms.Results: The allele and genotype distribution of rs807185 in ATG4 A were statistically different between the abdominal aortic aneurysm group and the control group(P <0.05).Results: Logistic regression analysis showed that the distribution of rs807185 in ATG4 A was statistically significant(P <0.05).The genotype of AA(homozygous mutant)at Rs807185 locus has a higher risk of developing abdominal aortic aneurysm.Conclusion: rs807185 locus mutation of ATG4 A gene may be a risk factor for the development of abdominal aortic aneurysm.