Closed-loop Inhibition Of Resting Tremor In Patients With Parkinson's Disease

With the aging of China,Parkinson's disease has become one of the most commom neurodegenerative diseases,the prevalence of Parkinson's disease of people in China who are over the age of 65 is about 1.7%,the main motor symptoms of PD are: tremor,rigidity,bradykinesia and postural instability.In the paper,for PD's resting tremor,based on the neurophysiology,we designed and developed a closed-loop system for tremor suppression in patients with PD.This closed-loop system collects the surface EMG signals of skeletal muscle of upper limbs which was related to resting tremor.After being filtered and amplified by anolog circuit,we use high-performance digital signal processing chip to deal with the surface EMG signals,and then calculate an eigenvalue to judge whether the patient was on tremor or not.Then according to different judgment,we control the build-in electrical stimulation module deliver a series of electrical stimulation pulse with certain parameters to the radial superficial nerve.The feedback information of the superficial radial nerve attenuated the excitability of PNs and also the ability for integrating signals from brain,so as to achieve the purpose of inhibiting the resting tremor in patients with PD.The electrical stimulation pulse test in this paper proved that the system can deliver an electrical stimulation pulse accurately,and the tremor detection rate test proved that the system can judge whether the patient with PD was on tremor or not accurately,and the experiments in patients with Parkinson's disease proved that the system did have some inhibitory effect on resting tremor.