Comparison Of Clinical Data Between Endometrial Carcinoma And Endometrial Carcinoma Complicated With Hypertension

Objective: by collecting endometrial carcinoma with hypertension patients and pure EC patients clinical data,analysis of the two groups of patients with general information,clinical manifestations,preoperative tumor marker,tissue differentiation,immunohistochemical and related parameters of solidification(PLT,PT,FIB,the Indian rupee,APTT)results such as characteristic,study the effect of hypertension on coagulation characteristics and tumor biological behavior of EC patients and its clinical significance.Methods: according to include and exclude standards,from January 2010 to December 2018 in lanzhou university first hospital treatment of department of gynaecology and clear diagnosis of endometrial adenocarcinoma patients,phase I and phase II and further surgery,the postoperative pathologic and immunohistochemical diagnosis of 100 patients,according to whether to have high blood pressure,divided into EC hypertension group(observation group)was 50 cases and pure EC group of 50 cases(control group),compared two groups of patients with general information,clinical manifestations,preoperative tumor marker,tissue differentiation and immunohistochemical characteristics and blood coagulation parameters such as the result,improve with high blood pressure early diagnosis,early treatment and quality of life of high-risk patients.Results: 1.The average age of patients in the observation group was 58.02±8.36 years old,and that of patients in the control group was 50.82±8.93 years old.The age of patients in the observation group was significantly higher than that of patients in the control group,and the difference was statistically significant(P < 0.05).In addition,compared with the control group,there were more patients in the observation group who suffered from massive vaginal bleeding,and the difference was statistically significant(P < 0.05).2.Compared with the control group,the expression of HE4 in preoperative tumor markers in the observation group was higher,and the difference was statistically significant(P < 0.05).However,preoperative tumor markers CA125,CA199 and CA724 were not significantly different in the two groups(P > 0.05).3.The results of immunohistochemistry comparison between the observation group and the control group showed that the positive rates of ER and PR in the observation group were significantly lower than those in the control group,and the difference was statistically significant(P < 0.05).The expression level of KI67 in the observation group(mean plus or minus standard deviation)was significantly higher than that in the control group(mean plus or minus standard deviation),and the difference was statistically significant(P < 0.05).However,the positive expression of P53 in the two groups was not statistically significant(P > 0.05).4.Comparison of coagulation parameters between observation group and control group showed that the changes of coagulation parameters in both groups were within the normal range.There was no statistically significant difference in the expression levels of coagulation parameters between the two groups(P > 0.05).There was no significant difference in FIB between the two groups(P > 0.05).The values of PT and APTT in the observation group were slightly higher than those in the control group,but the difference was only statistically significant(P < 0.05).Conclusions: 1.There were differences in age between EC patients and EC patients with hypertension.EC patients with hypertension are closely related to massive vaginal bleeding.In clinical work,we must pay close attention to such patients with high risk factors,carry out relevant examinations in time,and achieve early diagnosis and treatment.2.The higher positive expression of HE4 in serum of EC patients with hypertension suggests that HE4 has certain clinical significance in the diagnosis of EC patients with hypertension,which can be applied in the early screening and diagnosis of endometrial lesions in such patients with high-risk factors.3.Compared with EC patients alone,the positive expression of ER and PR in EC patients with hypertension was lower,and the positive expression of KI67 was higher,indicating that hypertension had certain influence on the prognosis of EC.4.There was no significant change in the coagulation function in patients with stage I and II EC combined with hypertension.