Changes And Clinical Significance Of Serum Lactic Acid,Ferritin,Hematoma And Surrounding CT Values After Traumatic Brain Injury In High Altitude Areas

Objective:Traumatic brain injury is an important global public health problem and a major cause of death and long-term disability worldwide.After the occurrence of traumatic brain injury,the body's energy metabolism will change,the inflammatory reaction will be aggravated,and various energy metabolism changes and secondary inflammatory reactions play an important role in the secondary traumatic brain injury.The purpose of this study was to study the changes in ferritin and lactic acid after traumatic brain injury and to study its changes and clinical significance.Method:Sixty patients with traumatic brain injury admitted to the Affiliated Hospital of Qinghai University from November 2017 to November 2018 were selected,30 of whom were tested for serum ferritin on days 1,3,7,and 14 after admission.In another30 cases,arterial blood lactate was detected on 1,3,7,and 14 days,and CT scans were performed at the same time.Compared with 30 patients with a clinical physical examination at the same time,serum ferritin and lactic acid were compared.To analyze the changes of serum ferritin and arterial blood lactate content in traumatic brain injury,combined with head hematoma and peripheral CT values,to explore the relationship between ferritin,lactic acid,and traumatic brain injury,and to study its changes and correlation.Results:The levels of ferritin and lactic acid in traumatic brain injury group were higher than those in the normal control group(P<0.05),and the duration was long.The ferritin content increased gradually after traumatic injury and reached the peak on the7th day.It decreased after 14 days but was still above normal.Lactic acid peaked on the first day after admission and gradually decreased to normal on the 14th day.Ferritin was negatively correlated with GCS score of brain injury,and lactic acid content was negatively correlated with GCS score of traumatic brain injury.The CT value of the head hematoma and the CT value of the peripheral edema decreased with time after the traumatic brain injury.Conclusions:1.Changes of ferritin and lactic acid in different periods after traumatic brain injury indicate energy metabolism,inflammatory reaction and steady-state changes after traumatic brain injury;GCS scores at a different time of ferritin and lactic acid,indicating that it can be As an indirect assessment indicator of the patient's condition.2.The expression of ferritin and lactic acid increased in the early stage of traumatic brain injury,and it was negatively correlated with GCS score,indicating that the increase of ferritin may be related to iron-induced free radical damage.The increase of lactic acid content not only indicates the metabolism of the body,but also the cranial internal cell metabolism disorders are related.3.The CT value of hematoma and edema after traumatic brain injury gradually decreased,indicating that the hematoma was decomposed and absorbed after traumatic brain injury,and the CT value of peripheral edema showed a decreasing trend,suggesting that the hematoma was decomposed and absorbed,and the surrounding brain tissue due to hematoma and injury gradually.There is an increase in edema.