| Objective1.To observe the clinical efficacy and safety of Chaihu-Shugan-San in treating postprandial discomfort syndrome(PDS)of functional dyspepsia of liver-stomach disharmony pattern.2.To observe the changes of plasma neuropeptide Y(NPY)and leptin(LEP)levels in patients with PDS before and after Chaihu-Shugan-San treatment,and to explore the possible mechanism of Chaihu-Shugan-San.3.To explore the relationship between plasma NPY、LEP and PDS.MethodsFrom January 2018 to January 2019,72 out-patients of outpatient department of digestive endoscopy in our hospital with liver-stomach disharmony type of functional dyspepsia postprandial discomfort syndrome who met the inclusion criteria were selected as the research object,and 36 healthy subjects from the physical examination center of our hospital were selected as the healthy control group.72 patients were randomly divided into the Traditional Chinese Medicine(TCM)treatment group(n=36)and the western medicine control group(n=36).The former was given Chaihu-Shugan-San,and the latter was given domperidone tablets.The course of treatment was 4 weeks.In this study,a total of 2 cases did not complete the treatment plan,among which 1 case was combined with medication,and 1 case withdrew automatically.The individual symptom score,TCM syndrome total score,and total effective rate of all patients were recorded respectively to judge the treatment effect before and after treatment.Plasma NPY and LEP levels were measured by enzyme-linked immunosorbent assay(ELISA)in healthy subjects and two groups of patients before and after treatment to explore the possible pathogenesis of this disease and the possible mechanism of Chaihu-Shugan-San.All data were analyzed by SPSS20.0 and the difference was statistically significant at P<0.05.Results1.There was no difference in the general situation of all subjects,such as sex,age,constitutional index and so on,and it was comparable(P>0.05).2.Comparison of single symptom scores: the scores of each single symptom in the two groups were significantly improved after treatment(P<0.05).The improvement degree of symptoms such as gastric distention,obvious after meal,early satiety,reduction of appetite,fullness in chest and hypochondrium,vexation and irritability,preference for sighing,dry mouth and bitter taste in the treatment group was superior to those in control group(P<0.05).And there was no significant difference in the improvement degree of belching frequency between the two groups(P>0.05).3.Comparison of total score of TCM syndromes: the total scores of TCM syndromes in both groups were improved compared with before treatment(P<0.05),and the improvement degree in the treatment group is better than that in the control group(P<0.05).4.Comparison of the curative effect of TCM syndrome: the total effective rate of the TCM treatment group was 88.57%,and that of the western medicine control group was 74.29%.The difference was statistically significant(P<0.05),indicating that the former was better than the latter in the overall clinical efficacy.5.Comparison of plasma NPY and LEP:the level of plasma NPY in PDS patients was lower than that in healthy people,and their LEP level was higher than that in healthy people(P<0.05).The plasma NPY levels of the two groups increased and LEP levels decreased respectively compared with those before treatment(P<0.05),and the improvement degree of the TCM treatment group was significantly higher than that of the western medicine control group,with statistically significant difference(P<0.05).Conclusion1.Chaihu-Shugan-San can significantly improve the clinical symptoms of PDS patients with liver-stomach disharmony pattern without obvious adverse reactions.2.The mechanism of Chaihu-Shugan-San in treating this disease may be to alter the levels of NPY and LEP in plasma.3.the level of plasma NPY in PDS patients was lower than that in healthy subjects,and LEP level in patients was higher than that in healthy subjects. |
