Study On Risk Factors Related To Cardiorenal Anemia Syndrome

Objective Patients with chronic heart failure often have renal insufficiency and anemia.When the three are present at the same time,it is called cardiorenal anaemia syndrome?CRAS?.The high incidence of CRAS,complicated pathogenesis,and extremely high mortality are serious challenges to human health.At present,the relevant risk factors are not clear.To explore the risk factors associated with the occurrence of cardiorenal anemia syndrome,in order to provide a basis for clinical prediction of the possibility of cardiorenal anemia syndrome.Methods Retrospective analysis of 207 patients with chronic heart failure admitted to the Department of Cardiology,Second Affiliated Hospital of Xi'an Medical University from October 2016 to October 2018.The general information such as age,gender,and medical history of the patients enrolled in the group were collected.Uniform blood collection by nurses in cardiology,detection of blood NT-proBNP,blood routine,liver and kidney function,blood lipids,electrolytes,myocardial enzymes and other biochemical indicators,and record the patient's cardiac ultrasound data.According to the level of hemoglobin and glomerular filtration rate,the cases were divided into non-CRAS group and CRAS group.The patients in this study were all patients with heart failure.If they had both renal insufficiency and anemia,they were classified as CRAS.The statistical data of general data,biochemical indicators and echocardiography were compared between the two groups.To further identify the risk factors for CRAS,the non-CRAS group was classified according to the 2016 ESC Heart Failure Guidelines for heart failure.According to the ejection fraction,the ejection fraction retention subgroup?HFpEF subgroup??EF?50%?,shot Three subgroups were included in the subgroup of blood scores?HFmrEF subgroup??40%?EF?49%?and the ejection fraction reduction subgroup?HFrEF subgroup??EF<40%?.The differences in basic data,laboratory indicators,and echocardiography between the three subgroups of the non-CRAS group and the CRAS group were compared.Multivariate logistic regression analysis was performed on the above statistically significant indicators to identify independent risk factors for CRAS.Results As a result,the incidence of CRAS in 207 patients with heart failure was 13%.Compared with the non-CRAS group,patients in the CRAS group had higher age,higher cardiac function scores,more with hypertension,diabetes,higher levels of NT-proBNP,K⁺,uric acid,LDH,and?-HBDH,and left atrial systole.The transverse diameter and left ventricular diastolic diameter are larger.The levels of Ca²⁺,Na⁺,total protein,TC,TG and LDL were lower,and the above differences were statistically significant?P<0.05?.Multivariate logistic regression analysis showed that advanced age,high uric acid level,and low total protein levels were independent risk factors for CRAS.Conclusion The incidence of CRAS in patients with heart failure was 13%.Advanced age,high uric acid levels,and low total protein levels are independent risk factors for CRAS.When these indicators change,we need to be vigilant,strengthen treatment and management,and try to avoid progression to cardiorenal anemia syndrome.