Expression And Clinical Significance Of FOXF1 Gene In Renal Cell Carcinoma And Adjacent Tissues

Backgrounds:Renal cell carcinoma is one of the most common malignant tumors in the urinary system,with high and yearly increasing morbidity and mortality.Surgery is very effective for localized renal cell carcinoma.For the latent onset and the lack of obvious clinical manifestations,many patients have metastasis when they are diagnosed with RCC.And this kind of patients respond poorly to radiotherapy,chemotherapy,cytokines,surgical and other treatments.FOXF1 gene and transcription factor play an important role in the occurrence and development of many diseases.This study is to investigate the expression of FOXF1 in renal cell carcinoma and its clinical significance.Methods : According to inclusion and exclusion criteria,60 specimens of paraffin-embedded RCC tissues and corresponding adjacent tissues were collected from the Department of Pathology,Affiliated Hospital of Yan'an University from September 2015 to September 2018.The distribution and expression of FOXF1 in RCC and adjacent tissues were detected by immunohistochemistry.The relationship between FOXF1 expression level and RCC and adjacent tissues,pathological type,pathological grade and clinical stage of RCC,age and sex of patients were analyzed.Results:1.The positive rate of FOXF1 expression is 28.3%(17/60)in RCC and 65.0%(39/60)in adjacent tissues.The difference has statistical significance(p<0.05).2.There is no significant difference in the positive expression rate of FOXF1 among RCC patients of different age,sex and pathological types(p>0.05).3.There is significant difference in the positive expression rate of FOXF1 among RCC patients of different pathological grades and clinical stages(p<0.05).Conclusion:1.The expression of FOXF1 is low in the tissue of RCC,but high in adjacent tissue of RCC.2.The expression of FOXF1 in RCC is related to the pathological grade and clinical stage,but not to the age,sex of patients and pathological type of RCC.