Clinical Observation Of MEBO Combined With RhEGF In The Treatment Of Burn Wounds

Objective:This study mainly studied the treatment of MEBO and topical recombinant human epidermal growth factor(rh EGF),and clinically observed the difference in clinical efficacy compared with MEBO alone and rh EGF alone in burn wounds.In order to find a more suitable treatment plan,to reduce the patient's mental and economic burden,shorten the hospital stay,accelerate wound healing,and provide relevant clinical basis for the application and development of MEBO and rh EGF.Methods:In this study,according to the "three-degree four-point method" of burn depth developed by the Chinese Burn Society,the size of the "nine-point method" diagnostic criteria,from November 2016 to March 2018 in the Department of Burns and Plastic Surgery,Yan'an University Hospital 90 patients with II° burns were used as subjects.All the subjects were completely randomized into 3 groups,which were:MEBO group,rh EGF group,and combined group,30 cases in each group.The rh EGF group was treated with a recombinant human epidermal growth factor solution for external use.MEBO group treated patients with direct wounds coated with MEBO.The patients in the combination group were treated with rh EGF solution to uniformly spray the wound surface,and then the MEBO was applied after the wound was absorbed.The time of wound healing,wound healing rate,scar formation and pigmentation were compared between the three groups.The relevant data were obtained and statistical analysis was performed using SPSS 25.0 software.Results :1.Comparison of general basic information There were no significant differences in gender,age,burn area,and injury factors between rh EGF group,MEBO group and combination group.The clinical data were in statistical order(P > 0.05).2.Comparison of healing time During the observation and treatment of the three groups of patients,a total of 90 patients were lost to 5 patients: 2 were lost to the rh EGF group,1 was lost to the MEBO group,and 2 were lost to the combined group.Among the remaining 85 patients,the healing time of the shallow II° wounds in the three groups was 8.66 ±1.63 days in the rh EGF group,9.58 ± 1.31 days in the MEBO group,and 7.64 ± 1.21 days in the combined group.The healing time of deep II° wounds in the three groups was 16.54 ± 2.29 in the rh EGF group,18.13 ± 2.75 d in the MEBO group,and 15.85± 1.71 d in the combined group.For the shallow II° wound and deep II° wound,the wound healing time of the three groups was statistically significant(P < 0.05),and the combined group < MEBO group < rh EGF group.3.Comparison of therapeutic effects There were 85 cases in the three groups,including 41 cases of shallow II degree wounds and 44 cases of deep II degree wounds.There was no significant difference in the healing rate of shallow II degree wounds between the three groups after 7 days of medication(P > 0.05),but it could not be considered that the healing rates of the three groups were different.The wound healing rate of combined group was significantly higher than that of rh EGF group and MEBO group after 14 days of deep II degree wound medication in the three groups.However,compared with MEBO group,the healing rate of rh EGF group could not be considered to be different from that of MEBO group.After 21 days of deep II degree wound medication,the healing rate of combined group was significantly higher than that of rh EGF group and MEBO group,while the healing rate of rh EGF group was not different from that of MEBO group.4.Scarring and pigmentation Of the 85 patients,41 had shallow II° wounds: 2 in the MEBO group had pigmentation,1 in the rh EGF group,and no pigmentation in the combined group,and no obvious scar formation in the three groups.In 44 cases of deep II° wound: 2cases of pigmentation in rh EGF group,2 cases of scar formation were obvious,3cases of pigmentation in MEBO group,1 case of scar formation,2 cases of pigmentation in group and 1 case of scar formation.Conclusion:In the treatment of II° burn wounds,the combination of MEBO and recombinant human epidermal growth factor can effectively shorten the healing time,improve the cure rate,and is significantly better than single-use recombinants.Epidermal growth factor or MEBO moist burn cream alone.