The Relationship Between Serum Omentin-1 And Carotid Atherosclerosis And Prognosis In Patients With Ischemic Stroke

Objective Our aim was to examine the association of omentin-1 levels with carotid plaque instability and stenosis degree among ischemic stroke patients.,and evaluate the association between omentin-1 levels and a poor functional outcome after ischemic stroke onset.Methods There were 266 consecutive patients with acute ischemic stroke in this prospective cohort study.Participants were admitted to the Department of Neurology of the Affiliated Hospital of Nantong University between October 2015 and June 2016.There were 171 males and 95 females in the study,and 172 healthy volunteers who had no history of cardiovascular or cerebrovascular diseases as the control group.Serum omentin-1 levels were assayed in all the people,a total of 173 acute ischemic stroke patientswas performed to evaluate the carotid plaque instability and stenosis degree by carotid ultrasound examinations.Multivariable logistic analyses were used to examine the association of serum omentin-1 levels with carotid plaque instability and stenosis degree.A total of 266 acute ischemic stroke patients was included in this study.All patients were prospectively followed up for 3 months after acute ischemic stroke onset and a poor functional outcome was defined as a major disability or death occurring during the follow-up period.A multivariable logistic model was used to evaluate the association between serum omentin-1 levels and the functional outcome of ischemic stroke patients at 3 months.Results1.Ischemic stroke patients had significantly lower levels of serum omentin-1 than healthy controls(55.9 [42.1-65.2] vs 122.2 [112.1-132.0] ng/ml,P<0.01).2.Ischemic stroke patients with unstable carotid plaque had significantly lower levels of serum omentin-1 than patients with stable plaque(53 [40.2-64.1] vs 61.8 [52.4-77.2] ng/ml,P<0.01).Subjects in the highest tertile of serum omentin-1 levels had a 0.31-fold risk of having unstable plaque compared with those in the lowest tertile(P<0.05),and its trend test was significant(P for trend=0.03).The integrated discrimination improvement was significantly improved in predicting carotid plaque instability when omentin-1 data was added to the multivariable logistic regression model.No significant association was detected between omentin-1 and moderate-severe carotid stenosis or occlusion.3.Ischemic stroke patients with poor functional outcome had significantly lower levels of serum omentin-1 than patients without poor functional outcome at the 3-month follow-up(50.2 [40.2-59.8] vs.58.3 [44.9-69.6] ng/ml,P<0.01).Subjects in the highest tertile of serum omentin-1 levels had a 0.38-fold risk of having poor functional outcome,compared with those in the lowest tertile(P<0.05).A negative association between omentin-1 levels and poor functional outcome was found(P for trend =0.02).The net reclassification index was significantly improved in predicting poor functional outcome when omentin-1 data was added to the multivariable logistic regression model.Conclusions Ischemic stroke patients had significantly lower levels of serum omentin-1 than healthy controls,higher omentin-1 levels were inversely associated with carotid plaque instability,but not associated with moderate–severe carotid stenosis or occlusion.Omentin-1 may predict carotid plaque instability of acute ischemic stroke patients in a way.Higher omentin-1 levels at baseline were negatively associated with poor functional outcome among ischemic stroke patients.Omentin-1 may have somepredicting effectsin poor functional outcome of acute ischemic stroke patients.