Transcatheter Arterial Chemoembolization For The Treatment Of Hepatic Hemangioma:A Retrospective Of Long Term Efficacy

Objective The purpose of this study is to evaluate the long-term effect of transcatheter arterial embolization(TAE)of hepatic hemangioma(HH).Methods A retrospective analysis was conducted on 137 patients with HH in 155 lesions at our institution from January 2005 to January 2017.TAE was carried out using Pingyang mycin-lipiodol emulsion and gelfoam particles in all patients.The maximum cross-sectional area of the tumor was measured and the average reduction rate and efficacy of the tumor were calculated after regular CT examination.The complications and liver and renal function were observed within 1 month and the complications were graded according to the Clavien-dindo classification criteria.Results The successful rate of technique of TAE was 100%,8.1ml(4~15ml)of Lipiodol and 8.4 mg(5~16mg)of Pingyang mycin in average was injected to each hemangioma.The average tumor size reduction rate of 6 months,6 months to 1years,1 to 3 years,3 to 5 years and 5 to 12 years were 61.6%,72.2%,83.9%,88.3% and 89.9% respectively,there were significant differences in the average tumor size reduction rate at three follow-up points in 3 years after TAE(P<0.05)and no significant differences between the remaining follow-up points over 3 years after TAE(P>0.05).The effective rates of 6 months,6 months to1 years,1 to 3 years,3 to 5 years and 5 to 12 years were 71.0%,81.2%,90.7%,93.4% and 94.9% respectively,there were significant differences in the four follow-up points over 6 months than 6 months after TAE(P<0.05)and no significant differences among the remaining follow-up points over 1 year after TAE respectively(P>0.05).There were significant differences in AST and ALT at a week after TAE than the preprocedure(P<0.05),moreover,AST and ALT averagely increased by 52.8U/L and 57.7U/L respectively,however,ALB,Tbil,Dbil,Bun and Cr were not significantly different from those before operation(P>0.05).1 months after TAE,there were no significant differences in AST,ALT,ALB,Tbil,Dbil,Bun and Cr compared with those before operation(P>0.05).Conclusion TAE appears to be a safe and useful treatment of HH and the long-term effect is significant.After embolization,the size of the tumor showed a regular pattern,which gradually reduced in one year after TAE,and the tumor tended to be stable after 1 to 12 years.