Analysis Of Risk Factors And Prognosis Of Postoperative Drainage Fluid In Patients With Breast Cancer

Objective:Postoperative drainage volume and drainage time in breast cancer patients reflected the response degree of the body to traumatic stress.Postoperative drainage fluid was related to postoperative complications,and it might have an impact on the prognosis of breast cancer patients.Our study was to analyze the risk factors of postoperative wound drainage,and to explore the effect of postoperative wound drainage on prognosis of patients with breast cancer.Methods:The clinical data of 732 breast cancer patients treated in Tianjin Medical University Cancer Institute and Hospital from January 2009 to June 2009 were retrospectively analyzed.SPSS24.0 software was used for statistical analysis.The relationship between age,height,weight,body mass index(BMI),hypertension,diabetes mellitus,coronary heart disease,surgical methods,mastectomy size,number of lymph node dissection,pathological features of tumor and the amount of drainage fluid and drainage time in patients with breast cancer were studied,and the risk factors of drainage fluid production in breast cancer patients were discussed.The prognosis of patients was also analyzed to explore the prognostic value of wound fluid(WF).Results:Univariate analysis showed that age,height,body weight,BMI,hypertension,tumor size,histological grade,surgical methods,mastectomy size and number of lymph node dissection were significantly associated with the total drainage volume,drainage time(P < 0.05).Body weight,BMI,tumor size,stage,surgical methods,mastectomy size,number of lymph node dissection and number of lymph node metastasis were significantly associated with the average drainage volume and the average drainage volume of the first 3 days(P < 0.05).Logistic multivariate regression analysis showed that BMI,mastectomy size were independent risk factors for total drainage volume,average drainage volume and drainage time(P < 0.05).BMI,mastectomy size and number of lymph node dissection were independent risk factors for average drainage volume of the first 3 days(P < 0.05).Prognosis analysis showed that tumor size,lymph node status,ER,PR and P53,molecular typing,staging and average drainage volume of the first 3 days had influence on overall survival time(OS)in breast cancer patients(P < 0.05).Tumor size,lymph node status,ER,PR,Ki67,P53,molecular typing and staging had influence on disease-free survival time(DFS)in breast cancer patients(P < 0.05).Total drainage volume,drainage time,average drainage volume had no influence on OS and DFS in breast cancer patients(P > 0.05).Multivariate analysis of prognosis: lymph node status,ER status were independent prognostic factors on OS in breast cancer patients.Tumor size,lymph node status,ER status,P53 status were independent prognostic factors on DFS in breast cancer patients.Conclusion:1.The occurrence of WF of breast cancer patients was influenced by many factors.Wound drainage volume and drainage time had relationship with age,body weight,BMI,hypertension,tumor size,mastectomy size and number of lymph node dissection and surgical methods.2.BMI and mastectomy size had important effects on volume of WF and drainage time in breast cancer patients.Patients with Obesity,larger mastectomy volume were more likely to have higher drainage volume and longer drainage time.Patients with more lymph node dissections had higher drainage volume3.Prognostic analysis showed that the average drainage volume of the first 3 days had influence on OS in breast cancer patients,but it was not an independent prognostic factor.Lymph node status,ER status were independent prognostic factors for OS in breast cancer patients.Tumor size,lymph node status,ER status,P53 status were independent prognostic factors for DFS in breast cancer patients.