Safty Of Morphine In Terminal Cancer Patients With Dyspnea

Objective: To investigate the safty of morphine in the treatment of dyspnea appeared in patients with Terminal cancer.Methods: From January 2010 to August 2014,we retrospectively collected clinical data from 170 Terminal cancer patients with dyspnea.All patients were divided into two groups according to treatment regimen:Morphine group and Non-Morphine group.The improvement of dyspnea,adverse reactions and survival time were observed and compared in both groups.Results: There are no significant differences in characteristics and baseline of patients between two groups.After treatment,VAS values decreased from(61.96 ± 7.48)mm to(24.46 ± 8.36)mm(p>0.05),Respiratory rate,heart rate and oxygen saturation has no significant differences.six case of nausea and vomit,eleven case of constipation,one case of respiratory depression in morphine group and three case of nausea and vomit,four case of constipation in non-morphine group.The median survival time of morphine group and non-morphine group is 71.5 days and 66.0 days respectively(p>0.05).Conclusion: Morphine is safe and effective for dyspnea management in Terminal cancer.It can significantly improve dyspnea and does not reduce the survival time of patients.