To Obverse The Efficacy Of Hydroxychloroquine Com-Bined With Minocycline In The Treatment Of Rosacea Based On Antera 3D Skin Analyzer

Objectives To observe the efficacy of hydroxychloroquine and minocycline in the treatment of rosacea,and to quantitatively evaluate the degree of remission of patients' skin topography and hemoglobin value with Antera 3D.Methods In this study,a total of 120 patients with erythematotelangiectatic and papulopustular rosacea who visited the dermatology clinic of North China University of Science and Technology Affiliated Hospital were selected and randomly divided into the groups of hydroxychloroquine group(A),minocycline group(B)and hydroxychloroquine combined minocycline group(C)respectively.Group A was given hydroxychloroquine 0.2g twice daily,group B was given minocycline 0.1g once every night,and group C was given hydroxychloroquine 0.2g twice daily and minocycline 0.1g once every night,the course of treatment is 8 weeks.Antera 3D was used to record imaging data at 0,2nd,4th and 8th week respectively,and then the hemoglobin value,elevation volume,depression volume and skin roughness were measured.Meanwhile,clinical symptoms and signs of the patients were recorded and scored,and the adverse reactions in the process of treatment were recorded.Results A total of 120 patients of rosacea were enrolled,and 17 were lost to follow-up.There were no statistical differences in gender,age,disease course and baseline clinical symptoms score among the three groups(P>0.05).1.The clinical symptom scores of each group were gradually reduced.Repeated measurement anova was used to analyze the clinical scores of the three groups,the differences in treatment main effect were statistically significant(P<0.05),and pairwise comparison was made between the two groups,the difference between the group C and the group A was statistically significant(P<0.05).The differences in time main effect and interaction were statistically significant(P<0.05),indicating that the clinical symptom score changed with time,and the change of the three groups were different,among which the clinical symptom score of group C showed the most significant changes and the effect was better.2.With the prolongation of treatment,the indicators such as hemoglobin values,elevation volumes,depression volumes and skin roughness of each group were gradually decreased.Similarly,repeated measurement anova was also used to analyze the hemoglobin values,elevation volumes,depression volumes and skin roughness of the three groups respectively,the differences in treatment main effect were all not statistically significant(P>0.05),indicating that there was no significant difference in the above four indicators among the three groups.The differences in time main effect and interaction were all statistically significant(P<0.05),showing that the measured values of each index change with the change of treatment time,and the change of the three groups were different,among which the change range of the above indexes in group C was relatively large,and the effect was more significant.3.After 2 weeks of treatment,the effective rates of the three groups were 6.1% of group A,11.4% of group B and 34.3% of group C,among which the clinical efficacy of group C and group A,as well as group C and group B were statistically different(P<0.0167),while the efficacy of group A and group B was not statistically different(P>0.0167).After 4 weeks of treatment,the effective rates of the three groups were 57.6% of group A,85.7% of group B and 94.1% of group C,with statistically significant differences in the efficacy between group A and group B,as well as group A and group C(P<0.0167),and no statistically significant differences in the clinical efficacy between group B and group C(P>0.0167).After 8 weeks of treatment,the effective rate of the three groups were 90.1% of group A,91.4% of group B and 94.3% of group C,and there was no statistically significant difference in efficacy between each two groups(P>0.05).4.There were 7 cases of mild adverse reactions in the treatment process,and all of them were gradually relieved after symptomatic treatment,and there was no statistically significant difference in incidence of adverse reactions between each two groups(P>0.05).Conclusions 1.Hydroxychloroquine and minocycline are effective in the treatment of rosacea,and compared with hydroxychloroquine or minocycline alone,the combined group has faster onset and better effect.2.In the treatment of rosacea,hydroxychloroquine and minocycline alone or in combination all could reduce the clinical scores,hemoglobin values,elevation volumes,depression volumes and skin roughness of the patients.Both hydroxychloroquine and minocycline were effective after 2 weeks of treatment and continued to function throughout the course of treatment.3.Antera 3D is simple to operate,it can objectively and accurately analyze the changes of skin topography and hemoglobin value.It can be used to evaluate the efficacy of rosacea patients in the treatment process.Figure5;Table14;Reference 52.