Retrospective Study The Relationship Between RDW And Adverse Outcomes After Rotational Atherectomy

Background and aims: In recent years,more and more attention has been paid to the red blood cell division width,which is associated with poor prognosis of various cardiovascular diseases,especially coronary heart disease.In coronary heart disease,severe calcification is a significant difficult problem.A very important method to solve the problem of the severe calcification lesion is RA(rotational atherectomy).The purpose of this study was to retrospectively investigate the correlation between segmental erythrocyte width and poor prognosis in patients with severe coronary calcification who were followed up RA for more than one year.Methods: A total of 212 patients were included in the study after RA in the wuhan union medical hospital from 2013 to 2017.27 patients who did not meet the inclusion criteria were excluded.The data of the rest of 185 patients were analyzed.All data were analyzed through SPSS23 software.For continuous variables,count(percentage)was used to measure classified variables,and chi-square test was used for comparison the data of MACE(+)and MACE(-),P<0.05 between the history of stroke and the standard use of statins was obtained,and the difference was statistically significant.The measurement data were compared by mean ± standard deviation and independent sample t test,and it can be concluded that the P<0.05 of RDW and hemoglobin was statistically significant,and the LVEF obtains P<0.1.Variables P<0.1(stroke,statins,RDW,hemoglobin and LVEF)were further included in the logistic regression equation for multivariate analysis to determine the independent predictors of MACE(+)after RA.RDW grouping was based on the ROC curve specificity and sensitivity relationship,combined with clinical expertise,to determine the optimal threshold for predicting MACE(major adverse cardiac endpoints)to be 13.5%.Results: In this study,the RDW differences between MACE(+)and MACE(-)are statistically significant by the single factor analysis(p < 0.05);Through the logistic multi-factors analysis there was no statistically significant difference(p = 0.442),which means it is possible not an independent predictor of poor prognosis after RA,and other factors,such as stroke,standardized use of statins and lower LVEF(left ventricular ejection fraction)have statistically significant difference,they may be independent predictors of poor prognosis after RA.Conclusions: In our single-center study,RDW probably not an independent predictor of poor prognosis after RA,but it may be have some correlation with major adverse cardiac events after RA.Other factors,such as history of stroke,standardized use of statins and lower left ventricular ejection fraction,are highly correlated with poor prognosis of patients after RA,and even predictive to some extent.