Pathophysiology Of Stress-induced Cardiomyopathy

Stress-induced cardiomyopathy or takotsubo cardiomyopathy is described as a transient reversible cardiomyopathy which typically occurs in postmenopausal women after emotional or physical stress.This cardiomyopathy is also recognized as a“syndrome” because it develops in conjunction with various diseases.The pathophysiology of this disease remains incompletely understood,Various etiologies are presumed to cause TTS,including catecholamine hypothesis,coronary vasospasm,microcirculatory dysfunction,estrogen deficiency,endothelial dysfunction,genetic factors,hypovolemia,hyponatremia,SIADH,Cancer,CA 125,IL-6 and IL-10.This article reviews the pathophysiology of stress-induced cardiomyopathy.