Correlation Between Tear Film And Meibomian Gland Function In Patients With Diabetic Retinopathy

ObjectiveTo explore the correlation between tear film and meibomian gland function in patients with diabetic retinopathy(DR),and to provide help for the early diagnosis and treatment of diabetic patients with dry eye disease.MethodsPatients were randomly selected from the department of the University-City Hospital Of Chongqing Medical University from April2018 to October 2018,who were diagnosed with type 2 diabetes by endocrinology and diagnosed with dry eye disease(DED)by ophthalmology.among them,30 patients without diabetic retinopathy were included in group A,30 patients with nonproliferative diabetic retinopathy(NPDR)were included in group B,30 patients with proliferative retinopathy(PDR)were included in group C,and 30 dry eye patients without diabetes were randomly selected as the control group,a total of 120 patients.All the patients were examined by standard patient evaluation of eye dryness(SPEED)?tear break-up time(BUT)?Schirmer I test(SIt)?lipid layer thickness(LLT)and meibomian gland secretion function.Thecorrelation between tear film and meibomian gland function in patients with diabetes and those in the control group and those in the three groups were compared.ResultsThere were no significant differences in SPEED scores?BUT?SIt?LLT and meibomian gland secretion between the without DR group and the control group(P>0.05).The degree of dry eye was slightly higher in the NPDR group than the without DR group,there were significant differences in SPEED score?BUT?SIt?LLT and meibomian gland secretion function(P<0.05).The degree of dry eye was more serious in the PDR group than the NPDR group,there were significant differences in BUT?SIt?LLT and meibomian gland secretion function(P<0.05).However,there was no significant difference in SPEED score between the control group and the without DR group(P>0.05).ConclusionWith the progression of diabetic retinopathy,patients with type 2diabetes are more likely to have dysfunction of the tear film and meibomian gland,and their abnormal ocular surface function is associated with the severity of DR.However,the SPEED score of patients with PDR is inversely reduced.Considering that it may be related to microvascular and corneal neuropathy,further research is needed.