Multicenter Study Of Diagnostic Procedures,Genetic Aberration Analysis, And First- Line Treatment Of Lung Cancer In Jiangsu Province,China

ObjectiveJiangsu Province,China,is highly developed economically and culturally,and has a high prevalence of lung cancer.We aimed to evaluate the diagnostic methods,genetic aberration analysis status,and first-line treatment models of lung cancer in Jiangsu Province.MethodsLung cancer patients diagnosed in 2016 at 22 tertiary care hospitals were evaluated.Demographic characteristics,tumor histology,staging,family history of lung cancer,auxiliary examinations,genetic testing,and first-line treatment were collected on discharge.Diagnostic and treatment data were analyzed by descriptive statistics.ResultsA total of 928 patients were enrolled.Chest computed tomography was the most frequently used imagological examination;pathology diagnosis was carried out mainly by bronchoscopy and transthoracic needle aspiration.The predominant first-line chemotherapy regimen of SCLC was platinum and etoposide.Stage I non-small cell lung cancer patients experienced surgical resection(97.9%);65.0% of stage II NSCLC received surgery and 50% of them experienced adjuvant chemotherapy;half of stage IIIA patients used first-line chemotherapy,but no radiotherapy simultaneously;for stage IIIB/IV patients,61.8% experienced systemic chemotherapy and 33.6% received molecular targeted therapy.First-line chemotherapy regimen of squamous lung cancers including platinum plus gemcitabine(35.2%),platinum plus docetaxel(33.6%),and platinum plus paclitaxel(24.6%).However,for non-squamous nonsmall cell lung cancers,platinum plus pemetrexed dominate.Detection of epidermal growth factor receptor(EGFR)mutations occurred in 27.2% of all patients,32.3% of NSCLC,and 46.8% of adenocarcinoma,the positive rates were 52.4%,52.6%,and 55.4% respectively.Detection rate of ALK,c-Met,ROS1,and RET were 12.0%,1.2%,2.8%,and 0.3%.86.5% of patients with EGFR mutations were treated with tyrosine kinase inhibitors.270(29.1%)patients didn't receive any treatment at diagnosis.ConclusionDetection rate of gene aberration was still low in Jiangsu Province.First-line treatment was primarily consilient with guidance,with few expectations.The percentage of patients receiving treatment at diagnosis should be elevated.