Advances In Neoadjuvant Therapy For Locally Advanced Esophageal Cancer

Esophageal cancer is one of the most common cancer diseases in the world,especially in east Asia,including China.In China,the incidence and mortality of esophageal cancer account for the 5th and 4th place of all malignant tumors respectively,It seriously affects people's health.Surgery is the main treatment for resectable esophageal cancer,However,due to the highly invasive nature,more than 70% of patients have been clinically diagnosed with advanced stage,Single treatment is not effective.Therefore,the selection of reasonable treatment options becomes very important.Because surgery is a major external intervention for patients,the incidence of postoperative complications is significant,in order to further extend the survival period of patients,reduce the treatment complications,improve the quality of life of patients,So people are turning their attention to neoadjuvant therapy.This article reviews the current situation of neoadjuvant therapy for locally advanced esophageal cancer,emphatically on neoadjuvant radiation,neoadjuvant chemotherapy,neoadjuvant chemoradiation,comparing research,discussion and analysis,and from esophageal squamous cell carcinoma,adenocarcinoma,two common pathological type,treatment effect of the main treatment method,benefit situation,the current situation were reviewed,aimed at understanding of the dynamic development of neoadjuvant therapy and research,explore the ideas for further research and combining with the actual cases of neoadjuvant chemoradiation the treatment process and efficacy of combined surgery,elaborates the results and analysis,It also confirmed the status of neoadjuvant chemoradiotherapy in the treatment of locally advanced esophageal cancer.At the same time,it also analyzed the problems in individual treatment combined with actual cases and the specific efficacy,and provided a reasonable basis for the preoperative comprehensive treatment of esophageal cancer,and aims to explore new idears for the follow-up research and provide more reasonable basis for the preoperative treatment of esophageal cancer.