The Antiplatelet Efficacy Of Indobufen In SCAD Patients

Purpose:We performed this study to oobserve the antiplatelet efficacy of Aspirin and Indobufen in SCAD patients.Methods:We selected 60 patients with SCAD.Then we divided into single antiplatelet therapy group and double antiplatelet therapy group.Single antiplatelet therapy group:A?100mg aspirin QD for 7days??I?100mg indobufen BID for 7 days?;dual antiplatelet therapy group A?100mg QD for 7days?and C?75mg clopidogrel QD for 7 days??I?100mg Indobufen BID for 7days?and C?75mg clopidogrel QD for 7 days?.The platelet inhibition levels of the four groups before drugs and after 7 days were compared.Thrombus atlas and PL-12 Platelet occupation assessment were used to assess platelet occupation.Venous blood models were taken at pre-treatment,and the seventh day after taking medications.The detection indexes were as follows:Maximum aggregation rate of arachidonic acid(MAR_?AA?),Maximum aggregation rate of Adenosine diphosphate(MAR_?ADP?),AA inhibition?ADP inhibition.Results:1.The results of A and I groups?A+C and I+C groups AA inhibition?MAR_?AA?were similar before treatment.The results of A+C group?A+I groups ADP inhibition?MAR_?ADP?were similar before treatment.2.After 7 days medication,the results of A and Igroups?A+C and I+Cgroups AA inhibition?MAR_?AA?were similar;the results of A+C group?I+C group ADP inhibition?MAR_?ADP?were similar.There were no side effects in I?I+C?A+C groups.A group had a fundus hemorrhage patient.Conclusions:In SCAD patient,the antiplatelet efficacy and safety of indobufen was similar to that of aspirin.