Predictive Value Of Platelet-to-lymphocyte Ratio In Patients With Percutaneous Coronory Intervention For Contrast Induced Nephropathy

Purpose:The purpose of this study was to explore whether the preoperative PLR can be the independent predictor of the CIN after Percutaneous Coronary Intervention(PCI)in patients with coronory disease.Methods:We enrolled a total of 310 patients who undergoing percutaneous coronary intervention(PCI)from March 2015 to April 2017 in our hospital.General information of patients was collected on admission.Hemogram,renal function,liver function and coagulation convention which include the Fibrinogen and Antithrombin ? and so on were collected before PCI.Four hours before surgery,all the selected patients were given 0.9 percent sodium chloride injection at the rate of 1ml/kg/h for continuous intravenous hydration,and then PCI.After the operation,furosemide 20 mg intravenous injection was given immediately,and 1500 ml sodium chloride injection was given for continuous hydration for 24 hours at the same rate.Renal function and other indicators were detected 48 hours after surgery.CIN was defined according to the current recognized CIN diagnostic criteria,and the selected patients were divided into CIN group and non-CIN group.To investigate whether there were statistical differences in PLR between the two groups.Finally,Logistic analysis was used to examine whether PLR could be used as an independent predictor of CIN.Result:CIN developed in 10 patients(3.2%).Baseline PLR was significantly higher in patients who developed CIN compared to those who did not,respectively;p=0.003).Multivariate analyses found that PLR [odds ratio(OR)1.007,95% confidence interval(CI)1.001-1.013;P=0.034] was independent predictors of CIN.The ROC curve analysis results showed that the area under the ROC curve was 0.745,and the PLR value was 125.729,which was the optimal critical value for CIN,with a sensitivity of 0.900 and a specificity of 0.577(95%confidence interval(CI)0.617-0.873,P=0.008).Conclusion:The PLR was an independent predictor of CIN after PCI in patients with coronary disease.