Application Of Acoustic Pharyngometry In Evaluation Of The Obesity Combined With OSAHS And The Efficacy Of Bariatric Surgery For OSAHS

Objectives:1.This study is designed to explore the correlation between acoustic pharyngometry parameters and the severity of Obstructive sleep apnea hypopnea syndrome?OSAHS?in obese patients.2.To evaluate the efficacy of bariatric surgery for OSAHS by acoustic pharyngometry.Methods:72 subjects were grouped according to body mass index?BMI?,including19 in the non-obese group?BMI<28?and 53 in the obese group?BMI?28?.According to obesity levels,the obesity group was 21 cases of grade 1 obesity?28?BMI<30?,11 cases of grade 2 obesity?30?BMI<35?,and 20 cases of grade 3 obesity?BMI?35?.Of the 53 patients,20 were obese and eligible for bariatric surgery.According to the apnea-hypopnea index?AHI?,20 patients with decommissioning were divided into groups,of which 15 patients?AHI?5?were eligible for OSAHS.All patients with weight loss were treated with Laparoscopic Sleeve Gastrectomy?LSG?.All subjects underwent PSG and supine position acoustic pharyngometry measurement and general body measurement.PSG,acoustic pharyngometry,and serum biochemical parameters?FBG,TG,TC,HDL-C,LDL-C?and other general body measurement were performed again in the bariatric surgery group after three months.Results:1.The minimum cross-sectional area of the pharyngeal cavity in the supine position was lower in obese patients than in non-obese patients?P<0.05?.The minimum cross-sectional area of the pharyngeal cavity in the supine position of grade 3 obese patients was significantly smaller than that of non-obese patients?P<0.05?.There was no difference in the minimum cross-sectional area of the pharyngeal cavity between the first-grade,second-grade and third-grade obese patients?P>0.05?.2.The minimum cross-sectional area of the pharyngeal cavity in the supine position was significantly negatively correlated with BMI?r=-0.242P=0.021?;the percentage of time with oxygen saturation lower than 90%?CT90?There was a significant negative correlation?r=-0.365 P=0.001,r=-0.213 P=0.039?,which was significantly positively correlated with lowest oxygen saturation?LSaO2??r=0.259 P=0.015?;supine position The minimum cross-sectional area of the pharyngeal cavity was significantly negatively correlated with the neck circumference and waist circumference?r=-0.344P=0.025,r=-0.224 P=0.038,respectively?.3.The minimum cross-sectional area of the pharyngeal cavity in the supine position was significantly increased in the supine position 3 months after the weight loss surgery?P=0.024?;the AHI and CT90 were significantly lower than those before the operation?P=0.040;P=0.045?,and the LSaO₂ was significantly higher than that before surgery.High?P=0.01?;BMI,neck circumference and waist circumference were significantly lower than those before operation?P<0.05?;Epworth score was significantly lower than that before operation?P<0.01?.Serum biochemical parameters FBG,TG,TC and LDL-C were significantly lower than those before operation?P<0.05?,and HDL-C was significantly higher than before operation?P<0.05?.Conclusions:1.Obesity,especially severe obesity,can cause the smallest cross-sectional area of the pharyngeal cavity to shrink.The minimum cross-sectional area of the pharyngeal cavity in the supine position of obese patients is consistent with the PSG monitoring results.Acoustic pharyngometry can be used for primary screening of OSAHS in obese patients.2.The minimum cross-sectional area of the pharyngeal cavity increases after weight loss surgery.The improvement of the minimum cross-sectional area of the pharyngeal cavity is consistent with the results of PSG monitoring,and acoustic pharyngometry can be used to evaluate the efficacy of weight loss surgery for OSAHS.The acoustic pharyngometry has the advantages of simplicity,economy,speed,non-invasiveness,etc.,and provides convenience for future clinical work.