| Objective: Lymph node Tuberculosis is a chronic-infectious disease caused by Mycobacterium tuberculosis and can occur anywhere in the body.It is characterized by early enlargement of a single lymph node,and multiple adjacent lymph nodes may be enlarged without timely detection and treatment.It presented as bead like realization or as a result of adjacent enlarged lymph nodes squeezing and conglutinating with each other to present a mass of lumps.Along with the progress of the disease,the pathological changes in the middle stage of the enlarged lymph nodes are often the liquefaction and necrosis of the enlarged lymph nodes and It leads to the destruction of lymph node structure and the increase of tension.Thus,the later stage of lymph node tuberculosis burst.After breaking,its broken face will not heal for a long time.At present,the main treatment for lymph node tuberculosis is integrated by traditional Chinese and western medicine.Western medicine mainly consists of oral antituberculous and immunomodulatory drugs or urgical treatment.But in recent years,Chinese medicine has achieved good results in the treatment of lymph node tuberculosis,whether oral Chinese medicine or external medicine.The purpose is to explore and study the efficacy of a new Chinese medicine preparation made of plaster and then applied to the affected area and whether it was effective for the treatment of lymph node tuberculosis nodule stage.Methods:1.Sixty patients with cervical lymph node tuberculosis in Hebei chest Hospital were randomly divided into three groups: Xiaoluo Sanjie San anti-tuberculosis with western medicine group(X group)?Maozhaocao anti-tuberculosis with western medicine group(M group)and anti-tuberculosis drug(D group),and there was no significant difference among the three groups.All three groups were treated with 2HRZE/6HR.X group on the basis of anti-tuberculosis treatment of 2HRZE/6HR the prescription of traditional Chinese medicine XiaoluoSanjie san,which using vaseline as a mediato and preparating of external application applied to the lesion of cervical lymph node tuberculosis.And smear thickness about 1-3mm for 8-12 hours.The M group on the basis of anti-tuberculosis treatment of western medicine plus Maozhaocao 10 g,which was using vaseline as a mediato and was applied to the diseased area,And smear thickness about 1-3mm for 8-12 hours.The D group was treated only with anti-tuberculosis treatment of 2HRZE/6HR.2.Three groups of patients were evaluated once every 2 months and observed for 4 cycles.They were observed the changes of treatment efficacy,TCM symptom integral and the adverse reactions incidence,so as to judge the reasonable curative effect.Results:1.The three groups were compared by statistical method 2 in the total effective rate after treatment and the X group was higher than that of the M group and D group(P < 0.05).2.Compared in TCM symptom integra,the M group was significantly different in pain,low fever,fatigue,night sweating and apocleisis(P < 0.05).But in the M and the D group only had significant differences in pain,low fever,fatigue and night sweating(P < 0.05),and there was no significant difference in anorexia(P > 0.05).The comparison among groups,compared with the M group and the D group,the X group was significantly differe:nt in pain,low fever,fatigue,night sweating(P < 0.05).However,there was no significant difference in anorexia between the among groups(P > 0.05).3.Safety evaluation of adverse events / adverse reactions: In this experiment,there was no serious adverse reaction,and the safety of grade was evaluated I.Conclusions:The effect of the anti-tuberculosis drug and Xiaoluo Sanjie San group on cervical lymph node tuberculosis was definite in unformed carbuncle stage,and the cure rate and effective rate of cervical lymph node tuberculosis were better than simple anti-tuberculosis group and anti-tuberculosis drug and Maozhaocao apply cointment group. |
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