Changes Of Telomere Length Before And After Treatment In Patients With First-episode Depressive Disorder

Objective:Although the mechanism of Depressive disorder(DD)is still unknown,some stud ies have found that telomere length is correlated with Depressive disorder,and telomere shortening and extension may be associated with Depressive disorder and antidepressant therapy.This study aims to explore:1.Changes in the acute phase of peripheral blood telomere length in patients with first-episode depressive disorder.2.Changes in the length of telomeres in peripheral blood of patients with first-episode depressive disorder before and after treatment with antidepressants in acute phase,providing objective biochemical indicators for the etiology,diagnosis and prognosis of depressive disorder.MethodsAccording to the inclusion criteria and exclusion criteria,patients with first-episode depressive disorder in outpatient and hospital were collected.A total of 29 patients with first-episode depressive disorder and 29 healthy controls matched in age,gender,and educational level were collected.General demographic data were collected and the Hamiton Deression Scae(HAMD)was applied to assess the symptoms of the studied subjects.29 patients with depressive disorder were antidepressant treatment for 8 weeks,both before and after treatment according to the bloods amples of standards and normal control group,according to the standard of the same blood samples,the unification of blood specimens of DNA extraction,weed out the unqualified samples,amplification,collectdata,using SPSS 22.0 statistical a nalysis of the results are:(1)independent samplet test was used to comparet difference of telomere length between 20 patients with depression before treatment and healthy control group.(2)independent samplet test was used to compare the difference of telomere length between 20 patients with depression after treatment and healthy control group;(3)paired samplet test was used to compare the relative telomere length of 20 patients with depression before and after treatment.Results:1.Compared with the healthy control group,patients with first-episode depressive disorder had shorter relative telomere length before treatment(t=-3.624,P<0.05).2.Compared with the healthy control group,patients with first-episode depressive disorder had shorter telomere length after treatment(t=-2.865,P<0.05).3.There was no statistical difference in the relative telomere length between patients with first-episode depression before and after treatment(t=-1.867,P>0.05).Conclusion:1.Relative telomere length abnormalities existed in patients with first-episode depressive disorder before acute treatment.2.The abnormal relative telomere length still exists in patients with first-episode depressive disorder 8 weeks after antidepressant treatment,suggesting that the abnormal relative telomere length in patients with first-episode depressive disorder may be aquality indicator of patients with first-episode depressive disorder.