Functional Consistency Of Resting Brain Regions In Patients Of Depression Disorder With Sleep Disturbance And Insomnia

Objective: This study used resting-state functional Magnetic Resonance Imaging(f MRI)technique and Regional Homogeneity(Re Ho)data analysis methods,to investigate whether there are brain dysfunctions in patients with insomnia and major depression disorder patients with sleep disturbance,and to analyze the commonality and specificity of brain function mediated by them.Trying to find neuroimaging markers with subtypes of major depression disorder,and further explaining the two-way relationship between depression and insomnia.Methods: According to the exclusion criteria,58 patients of major depression disorder,24 patients with insomnia,and 30 controls with age,gender and years of education were collected.The Hamilton Depression Scale-17(HAMD-17),the Hamilton Anxiety Scale-14(HAMA-14)and the Pittsburgh Sleep Quality Index Rating Scale(PSQI)were used to assess mood and sleep quality of all subjects.According to the PSQI score of 6 were used as the threshold value,the components of major depression disorders were two groups,31 patients were major depression disorders with sleep disturbance,and 27 patients were major depression disorders without sleep disturbance.All subjects underwent f MRI scans.Based on the MATLAB 2013 b platform and DAPBI software to preprocess the f MRI data and Re Ho index calculation.Firstly,the Re Ho variance analysis of the brain regions of the four groups was used to obtain the mask of the different brain regions.Based on the mask,the comparison between the groups was performed.Compared with the group of major depression disorder with sleep disturbance,the overlapping brain regions with different insomnia compared with controls is significant overlapping brain regions.All statistical outcomes are performed with Alpha Sim correction,with P<0.001 and clusters voxels > 6 or P < 0.005 and cluster voxels > 12,After correction P<0.05 is considered as statistically significant brain regions.Results: 1.Comparison of brain regions between depressive disorder with or without sleep disturbance,insomnia and controls: the right precentral gyrus,bilateral middle temporal gyrus,the left cerebellar,bilateral middle frontal gyrus,and the left inferior frontal triangular part(Alpha Sim,P<0.005).2.Compared with the brain function of the controls,the insomnia group showed higher Re Ho in the right precentral gyrus,the left middle frontal gyrus and left cerebellar(Alpha Sim,P<0.005).3.Compared with the group of patients of depressive disorder without sleep disturbance,the depressive disorder with sleep disturbance showed higher in Re Ho in the left middle temporal gyrus,the left inferior frontal orbital part,he left inferior frontal triangular part,and bilateral middle frontal gyrus(Alpha Sim,P<0.001).Compared with the insomnia group,the Reho decreased in the left cerebellar,the right precentral gyrus,the left inferior frontal orbital part,the right inferior frontal triangular part,and the left middle temporal gyrus(Alpha Sim,P<0.001).Compared with the brain function of the control group,the Re Ho increased in the bilateral middle temporal gyrus,the left middle frontal gyrus,and the left inferior frontal triangular part(Alpha Sim,P<0.005).4.Compared with the group of major depression disorder with sleep disturbance,the overlapping brain regions with different insomnia compared with controls is is the left middle frontal gyrus(Alpha Sim,P<0.005).Conclusion: 1.Functional abnormalities in the precentral gyrus,cerebellum and middle frontal gyrus are of great significance in the pathogenesis of insomnia.2.The left middle frontal gyrus and the left middle temporal gyrus may mediate important neurobiological mechanisms associated with major depressive disorder with sleep disturbance,and are specific imaging indicators for the diagnosis of subtypes of this depressive disorder.3.The left middle frontal gyrus plays an important role in the major depressive disorder with sleep disturbance and insomnia.