Changes Of Serum Irisin And Chemerin In Newly Diagnosed Non-obese Type 2 Diabetes Mellitus

Objective:To investigate the changes of serum irisin and Chemerin in newly diagnosed non-obese type 2 diabetes mellitus,and to observe the relationship between irisin and some metabolic indexes.Methods:1.Subjects:Fifty patients with newly diagnosed type 2 diabetes mellitus(T2DM group)were selected in the department of endocrinology in the second hospital of Shanxi medical university from March 2018 to August 2018.Fifty patients with normal glucose tolerance(NGT group)were included in the physical examination center of our hospital during the same period,whose age and gender were mached with T2DM group.2.Clinical data collection:All subjects were recorded for sex,age,height,weight,systolic blood pressure(SBP),diastolic blood pressure(DBP),fasting blood glucose(FPG),2-hour postprandial blood glucose(2h PG),fasting insulin(FINS),glycosylated hemoglobin(HbA1c),blood lipid,serum irisin and chemerin.Body mass index(BMI),islet beta cell function index(HOMA-beta)and homeostasis model insulin resistance index(HOMA-IR)were calculated.Result1.The comparison of basic clinical data between the two groups:There was no significant difference in gender,age,BMI,SBP,DBP,HOMA-beta and TC levels between the two groups(P>0.05).FPG,2h PG,FINS,HbA1c,HOMA-IR,TG and LDL-C levels in the T2DM group were significantly higher than those in the NGT group(P<0.05 or P<0.01),and HDL-C levels were significantly lower than those in the NGT group(P<0.05).The serum irisin level in T2DM group was significantly lower than that in NGT group[(3.34+0.59)vs(3.99+0.71)ug/mL,P<0.01];the chemerin level was significantly higher than that in NGT group[237.77(200.74,279.95)vs 120.08(99.64,136.82)ng/ml,P<0.01].2.The correlation analysis between irisin and chemerin with indexes:Spearman correlation analysis showed that irisin was negatively correlated with FPG,2h PG,HbA1c,HbA1c,FINS,HOMA-IR(r_s=-0.304,P=0.002)?(r_s=-0.323,P=0.001)?(r_s=-0.307,P=0.002)?(r_s=-0.415,P<0.001)?(r_s=-0.336,P=0.001),and positively correlated with HDL-C(r_s=0.252,P=0.011).Chemerin was positively correlated with FPG,2h PG,HbA1c,FINS,HOMA-IR,LDL-C,TG(r_s=0.637,P<0.001)?(r_s=0.673,P<0.001)?(r_s=0.752,P<0.001)?(r_s=0.705,P<0.001)?(r_s=0.761,P<0.001)?(r_s=0.211,P=0.036)?(r_s=0.290,P=0.003),and negatively correlated with HDL-C(r_s=-0.204,P=0.042).Irisin was negatively correlated with chemerin(r_s=-0.256,P=0.010).3.Regression analysis:Multiple stepwise regression analysis showed that 2h PG and HDL were independent influencing factors of serum irisin level(P<0.01 or P<0.05).2h PG,HOMA-IR and TG were independent influencing factors of serum chemerin level(P<0.01 or P<0.05).Logistic regression analysis showed that serum irisin was a protective factor of glucose metabolism(OR:0.265,95%CI:0.126,0.556,P<0.01),while serum chemerin was a risk factor(OR:1.088,95%CI:1.047,1.131,P<0.01).Conclusion:1.Compared with the normal glucose tolerance group,the serum irisin level of newly diagnosed non-obese patients with T2DM decreased significantly and the chemerin level increased significantly,suggesting that irisin and chemerin may be related to T2DM.2.Serum Irisin was negatively correlated with FPG,2h PG,HbA1c,FINS,HOMA-IR and positively correlated with HDL-C,while chemerin were positively correlated with FPG,2h PG,HbA1c,FINS,HOMA-IR,LDL-C,TG and negatively correlated with HDL-C,suggesting that irisin and chemerin may be related to glycolipid metabolism and IR.3.Serum irisin is a protective factor affecting glucose metabolism,whlie serum chemerin is a risk factor affecting glucose metabolism,and serum irisin is negatively correlated with chemerin,suggesting that there may be interaction between irisin and chemerin in the development of T2DM.