Analysis Of Therapeutic Effect Of Glucocorticoid In Severe Drug-induced Liver Injury

Objective:To observe the efficacy and safety of glucocorticoids in the treatment of severe drug-induced liver injury.Methods:Fifty-nine patients with drug-induced severe liver injury were selected and divided into steroids use group(n=29)and no steroids use group(n=30).The no steroids use group were treated with routine drugs to protect liver and reduce jaundice,while the steroids use group were treated with glucocorticoid pulse therapy on the basis of this treatment.Results:1.Compared with the peak biochemical indexes of patients in the steroids use group and the no steroids use group,there were statistical differences in ALT,AST,ALB,TBil,DBil,HGB.Patients in the steroids use group had higher bilirubin levels,lower transaminase and lower albumin,which indicated that patients in the steroids use group were more seriously.2.The median time of 50% decrease of TBil in steroids group and no steroids use group were 9 days and 12 days,respectively,with statistical difference(p=0.035),indicating that short-term use of steroids therapy could quickly shorten the time for the recovery of bilirubin.3.The adverse reactions of the no steroids use group and the steroids use group were3(10%)and 5(17.2%)respectively,and there were no statistical difference between the two groups,which were improved after symptomatic treatment.Conclusion:The short-term use of glucocorticoids has certain value in DILI.