The Role Of Induced Sputum And NLR、PLR In The Assessment Of Asthma

Objective:To investigate the role of induced aputum and neutrophil-lymphocyte ratio（NLR）and platelet-lymphocyte ratio（NLR）in assessing the severity of asthma patients.Methods:The clinical data of 85 patients with acute asthma who were hospitalized from January 2017 to January 2018 in the First Hospital of Shanxi Medical University were retrospectively.General information such as age,sex,BMI,duration of disease and smoking rate were collected.Induced sputum,blood cell analysis and calculation of neutrophil-lymphocyte ratio（NLR）and platelet-lymphocyte ratio（PLR）,pulmonary function,arterial blood gas and other clinical data.According to the severity of the disease,it was divided into three groups:light,medium and severe.According to the induced sputum,it was divided into four groups:eosinophil type（EOS type）,neutrophil type（NEU type）,mixed cell type（MIX type）,and paucigranulocytic type（PAU type）.The difference between the severity of the disease and the different phenotypesResults:NLR and PLR were positively correlated in blood cell analysis（r=0.750,p<0.001）,NLR was negatively correlated with FEV₁/FVC（r=-0.359,P=0.011）,and NLR was negatively correlated with FEV₁%pred（r=-0.284,P=0.048）,PLR was negatively correlated with FEV₁%pred（r=-0.364,P=0.010）.The phenotypic composition ratio of asthma patients with different severity was statistically significant（x²=12.42,P<0.05）.NLR and PLR were significantly higher in patients with severe asthma than in mild and moderate（P<0.01）.Sputum EOS%,sputum NEU%and blood EOS%,blood NEU%were compared between the four groups of inflammatory phenotypes,the difference was statistically significant（P<0.01）.NLR and PLR were significantly elevated in patients with NEU-type asthma,and the difference was statistically significant among the four groups（P=0.01,P=0.04）.Conclusion:The phenotypic composition ratio of asthma patients with different severity.The higher NLR and PLR Values,the higher the sputum NEU%,the greater the possibility of NEU-type asthma.The more serious the disease,and the worse the pulmonary function.