Study On The Correlation Between Obstructive Sleep Apnea-Hypopnea Syndrome And Constitution Of TCM In Nanchang

Objective: To explore the general information characteristics of patients with obstructive sleep apnea hypopnea syndrome(OSAHS)in Nanchang and the correlation between various physiological indicators and constitutional types of traditional Chinese medicine,to understand the constitutional change trend of OSAHS patients in Nanchang,and the physiological change characteristics and rules of OSAHS patients under different constitutional conditions,so as to provide epidemiological data for the prevention of OSAHS in Nanchang.It will provide certain basis and indication for the direction and research of TCM treatment of OSAHS in the future.Method: From March 2017 to December 2018,198 patients who complained of snoring with apnea or daytime sleepiness were admitted to the hospital affiliated to Jiangxi University of Traditional Chinese Medicine.They were monitored by polysomnography(PSG).The results showed that 198 patients met the diagnostic criteria of OSAHS in Nanchang.Record their general information(hospitalization number or medical record number,name,place of residence,time of residence,age,sex,height,weight,smoking and drinking history,history of hypertension,contact mode,etc.)and fill in the basic information questionnaire of patients with obstructive sleep apnea hypopnea syndrome and the classification and determination form of constitution of traditional Chinese medicine.Professional TCM physicians classify the constitution of TCM,and statistics the relevant physiological indicators of polysomnography monitoring(OSAHS severity,apnea hypopnea index,average oxygen saturation,snoring index,minimum oxygen saturation and the longest apnea time,etc.).To observe the general information characteristics of OSAHS patients in Nanchang area,the distribution of constitution types in traditional Chinese medicine and the correlation between physiological indexes and constitution.Result:1.The comparison of sex and age of OSAHS patients in Nanchang area:138 males(69.7%)and 60 females(30.3%)had sex ratio of 2.3:1;the majority of OSAHS patients aged 41-60 years were 106(53.54%).The average age of males was 51.75±13.10 years,and the average age of females was59.62±10.40 years.The onset age of male OSAHS patients was relatively younger than that of females(P<0.05).2.Overweight and obese OSAHS patients accounted for 80.3%,smoking and drinking history of OSAHS patients accounted for 62.1%,and hypertension history of OSAHS patients accounted for 71.7%.3.There were 81 patients with mild illness(40.91%),75 patients with moderate illness(37.88%)and most patients with mild or moderate illness;the age of patients with severe OSAHS was younger than those with mild illness(P<0.05);BMI of patients with severe OSAHS was larger than that of patients with moderate illness(P< 0.05);There was correlation between them(P<0.05).4.The frequency of each constitution of OSAHS patients in Nanchang area was: phlegm-dampness constitution in 51 cases(25.8%),Qi deficiency constitution in 39 cases(19.7%),blood stasis constitution in 35 cases(17.7%),dampness-heat constitution in 22 cases(11.1%),Yang deficiency constitution in 10 cases(5.1%),Yin deficiency in 8 cases(4%)calmconstitution in 8 cases(4%)and special constitution in 3 cases(1.5%).5.There was significant difference in sex proportion between the types of phlegm-dampness and Qi-depression in OSAHS patients(P <0.05);there was no significant difference in age distribution of each constitution in OSAHS patients(P >0.05).Obese OSAHS patients accounted for 29.8%.Among them,phlegm-dampness,blood stasis and damp-heat were the highest,and there was statistical significance between body constitution and obesity(P <0.05).The disease severity of OSAHS patients was mainly mild to moderate,mild to blood stasis and damp-heat,and severe to phlegm-dampness and Qi deficiency.There were statistical differences in the severity of OSAHS among different constitutions(P <0.05).The constitution of SAHS patients with hypertension is mainly phlegm-dampness,Qi deficiency and blood stasis.There is statistical difference between OSAHS patients with different constitutions and hypertension(P <0.05).6.In the study of TCM constitution and physiological indexes of OSAHS,it was found that AHI had an effect on phlegm-dampness,Qi deficiency and blood stasis(P <0.05),but the average oxygen saturation,snoring index and the longest duration of apnea had no correlation with phlegm-dampness,Qi deficiency and blood stasis(P >0.05).Conclusion:1.The incidence of OSAHS in Nanchang area is mainly male,and male and female have a certain incidence at all age stages,but male is younger than female.2.Obesity,smoking and alcohol consumption are risk factors for OSAHS.The severity of OSAHS and hypertension interact with each other,and the severity of OSAHS is aggravated with the increase of body weight.3.Phlegm-dampness,Qi deficiency and blood stasis are the main constitutional types of OSAHS patients in Nanchang,among which phlegm-dampness is the most common.4.The constitutional types of TCM have certain correlation with OSAHS patients' gender,severity of disease,obesity and hypertension.Apnea-hypopnea index has influence on phlegm-dampness,Qi deficiency and blood stasis,but the average oxygen saturation,snoring index and the longest duration of apnea have no obvious correlation with these three constitutions.