Efficacy Of Interval Theta Burst Stimulation In Schizophrenia

Objectives: To explore the efficacy of intermittent Theta Burst Stimulation model repetitive transcranial magnetic stimulation(iTBS)on the clinical efficacy and cognitive function of schizophrenia in patients with schizophrenia.Methods: This study was a multicenter randomized double-blind,placebo-stimulated controlled clinical trial.Forty-five patients who were diagnosed with schizophrenia were randomly divided into study group(n =21)and control group(n=24).The repetitive transcranial magnetic stimulation of iTBS model was performed 10 sessions.Department,the two groups were given true stimulation and placebo-stimulus intervention.Drug treatment remained unchanged during the study period.(HAMD-24)and Hamilton Anxiety Scale(HAMA)were performed in the group of patients who were screened at the end of the treatment intervention and 2 weeks after the end of the treatment.The positive and negative symptoms scale(PANSS),Hamilton Depression Scale(HAMD-24),the General Clinical Efficacy Scale(CGI)were used to elevate the clincal symptoms of the patients.The Matrics consensus cognitive battery were used to evaluate cognitive function of subjects at the time of screening and the end of treatment.The clinical symptom scale score was processed by the generalized estimation equation,and the results of cognitive function evaluation were processed by repeated measurement of variance analysis.Results:(1)There was no significant difference in the demographic characteristics and clinical symptoms between the two groups at baseline(P>0.05).(2)There was no significant difference in the main effect of PANSS-positive symptoms,the main effect of time,and the interaction between time and grouping(P>0.05).In PANSS-negative symptoms,the interaction of time and group has statistical meaning(P <0.05).In PANSS general pathological symptom score,the interaction between time and group was at the end of treatment,and the interaction between time and grouping was statistically significant(P <0.05)at the end of treatment and 2 weeks after the end of treatment.(P <0.05).The interaction between time and grouping was statistically significant(P<0.05)at the end of treatment,and the total score of PANSS scale was statistically significant(P<0.05).(3)In the HAMD scale,at 2 weeks after the end of treatment,the interaction effect between time and grouping was statistically significant(P <0.05).On the HAMA scale,at the end of treatment and 2 weeks after the end of treatment.The interaction between time and grouping was statistically significant(P <0.05).(4)On the SI test,the effect of time and grouping was statistically significant at the end of treatment(P<0.05).On the GI score,the difference was statistically significant only in the main effect of grouping(P <0.05).On the EI scale,it was statistically significant only in the main effect of the group(P<0.001).(5)In the sub-test of MCCB,the difference was statistically significant(P<0.05)before and after treatment in symbol coding,spatial breadth and same pairing.Conclusions: Repeated transcranial magnetic stimulation of cerebellar vermis in iTBS can improve the clinical symptoms and emotional and emotional symptoms of patients with schizophrenia,and the cognitive function of patients with schizophrenia is improved to a certain extent.