Relationship Between Thyroid Disease And Iodine Nutrition,Th17 Cells And Related Factors

Objective To obtain the detection of thyroid dysfunction in healthy people through investigation and research;to assess the iodine nutritional status of the population;to understand the possible influencing factors of thyroid dysfunction,and to provide evidence and strategies for prevention and control of iodine deficiency or iodine-induced thyroid disease guide.By observing the role of Th17 cells and their related cytokines in different thyroid dysfunction diseases to explore their role in thyroid dysfunction-related diseases,thus to provide the experimental basis for the anti-inflammatory treatment and immunological control of the thyroid dysfunction.Methods Blood and urine samples were collected for TSH,FT4,FT3 and thyroid autoimmune antibodies TPO-Ab,TG-Ab and urine iodine test;Adopt a unified and pre-surveyed questionnaire and start a questionnaire after getting informed consent from all the subjects.The multi-class logistic regression model was used to analyze the influencing factors of different thyroid diseases.Spearman linear correlation analysis for correlation between groups.The levels of Th17 cells and their related factors like IL-6,IL-17,IL-23 and TGF-?1were detected in some populations.Using the analysis of variance to compare between various groups,?~2 test for the comparison of the rates.All analyses were tested with?=0.05.Results 1 The detection rate of simple thyroid autoimmune antibodies was the highest,at 19.86%.Followed by abnormal thyroid-related antibodies with abnormal thyroid function,11.13%;the detection rates of hypothyroidism,hypothyroidism,hyperthyroidism,and methylene guanidine were 4.10%,7.78%,1.35%,and 0.79%,respectively.2 The median urinary iodine(MUI)of different thyroid function groups was 142.72?g/L,127.11?g/L,162.56?g/L,150.30?g/L,137.80?g/L,137.63?g/L,and 134.67?g/L,respectively.The median urinary iodine levels in different age groups were also in the appropriate range of iodine(MUI:100~199?g/L).3 Risk factors for thyroid dysfunction were age(OR=1.03,95%CI:1.01,1.04),female(OR=1.55,95%CI:1.09,2.23),and overweight(OR=1.32,95%CI:1.02,1.71),iodine excess(OR=1.57,95%CI:1.04,2.37).Risk factors for abnormal thyroid antibody were age(OR=1.01,95%CI:1.001,1.02),female(OR=3.26,95%CI:2.27,4.68),and significant adverse mood(OR=1.39,95%CI:1.03,1.89),radiation contact frequency(OR=1.16,95%CI:1.01,1.36).Risk factors for antibody abnormalities with thyroid dysfunction were age(OR=1.02,95%CI:1.01,1.03),female(OR=5.94,95%CI:3.48,10.15),radiation exposure frequency(OR=1.29,95%CI:1.08,1.57),family history of thyroid disease(OR=1.46,95%CI:1.08,1.97).4 The proportion of Th17 cells in the thyroid antibody abnormal group was higher than that in the normal control group(P<0.05).The expression levels of IL-6,IL-17,IL-23 and TGF-?1 in the abnormal thyroid antibody group were higher than those in the normal group.The expression level of Th17 cells is a risk factor for the occurrence of simple antibody abnormalities,and IL-17 factor levels are risk factors for different thyroid dysfunction.Conclusion The iodine nutrition of this population is in an appropriate state of iodine.Age,gender,overweight,significant adverse emotions,iodine excess,frequency of radiation exposure,and family history of thyroid disease are risk factors for thyroid disease.High expression of Th17 cells and IL-17 factors may play an important role in thyroid autoimmune antibody abnormalities.