| Objective By studying the relationship between serum homocysteine levels and mitral valve flow velocity,further explore its clinical value in patients with diastolic heart failure.Methods By inclusion and exclusion criteria,randomly collecting Eighty-five patients with diastolic heart failure diagnosed in our department of cardiology and One hundred and sixteen healthy people who are outpatient medical examination from November 2017 to January 2019.The basic clinical data of the patients were recorded,including age,gender,smoking history,drinking history,family history.All subjects were fasted for 8 hours and then venous blood was taken on an empty stomach in the morning on the day of the hospital to check liver function,renal function,homocysteine.,troponin,brain natriuretic peptide,and cardiac color doppler ultrasound examination during the hospital,recording the maximum mitral early diastolic flow velocity,the maximum mitral late diastolic flow velocity(E peak,A peak).According to the E/A value,patients with diastolic heart failure were divided into two subgroups: E/A≥1 group(group A,41 cases),E/A<1 group(group B,44 cases);Based on the level of homocysteine,patients with diastolic heart failure were divided into two subgroups:patients with diastolic heart failure and high homocysteine group(group D,55 cases),and a group with diastolic heart failure normal homocysteine(Group E,30 cases);In the healthy person group(group C),116 patients were divided into two subgroups according to the level of homocysteine,which were healthy human high homocysteine group(group F,30 cases),healthy human normal homocysteine group(group G,86 cases).Statistical analysis was performed according to the grouping and conclusions were drawn.Results There were no statistically significant differences in the general clinical data between group A and group B and group C,group D and group E,group F and group G: age,gender,smoking history,drinking history,and family history of heart disease(P>0.05).The levels of Hcy and BNP in group A were significantly higher than those in group B and C(P<0.05).The levels of Hcy and BNP in group B were significantly higher than those in group C(P<0.05).The level of peak E in group A was significantly higher than that of group B(P<0.05).The level of peak A in group A was significantly lower than that in group B(P<0.05).The level of Hcy in group A was significantly higher than that in group B,the difference was statistically significant(P<0.05);In the heart failure group(group A B),Hcy was positively correlated with E peak,and the Pearson correlation coefficient(r value)was equal to 0.371 greater than 0.The difference was statistically significant(P=0.000,P<0.05).The Hcy of the heart failure group was negatively correlated with the A peak,and the R value was equal to-0.222 and less than 0.The difference was statistically significant(P=0.041,P<0.05).The levels of peak E,E/A and BNP in group D were significantly higher than those in group E(P<0.05).The level of peak A in group D was significantly lower than that in group E(P<0.05).There were no significant differences in the levels of peak E,peak A,E/A and BNP between group F and group G(P>0.05).Conclusions1.Hcy and mitral valve flow velocity have important clinical value in patients with diastolic heart failure.2.High Hcy is associated with mitral valve flow velocity in patients with diastolic heart failure,positively correlated with E peak,and negatively correlated with A peak;3.High Hcy in patients with diastolic heart failure may has effect on mitral valve flow velocity.In clinical work,we actively intervene in the level of high Hcy in patients with diastolic heart failure,which may have important clinical significance for the treatment and prognosis of patients with diastolic heart failure.4.There was no significant correlation between high Hcy levels and mitral valve flow velocity in healthy people. |
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