Analysis Of Risk Factors For Coronary Artery Disease And Coronary Artery Lesion Counts

Objective:In this study,the risk factors of coronary heart disease,especially blood lipids,apolipoproteins,homocysteine,high sensitivity C-reactive protein and other biochemical indicators were statistically analyzed to investigate the relationship between coronary artery disease and coronary artery lesion counts.Provide relevant theoretical basis for clinical diagnosis,treatment and prevention of coronary artery disease.Material and methods:Subjects were randomly selected from 2014.4-2017.2 in the Department of Cardiology,Hangzhou Second People’s Hospital.A total of 1318 subjects were selected,864 cases and 454 controls.All obtained data were statistically processed and analyzed by statistical software SPSS 20.0 version.Quantitative data were statistically described using mean±standard deviation（（?）±S）or median and interquartile range M(P₂₅,P₇₅),and t-test or one-way ANOVA were used for comparison between groups.The categorical data were statistically described by percentage（%）,and the chi-square test（χ²）was used for comparison between groups.All tests were statistically significant at P<0.05.Results:1)Age,gender,systolic blood pressure,pulse pressure,smoking,alcohol consumption,fasting blood glucose（FBG）,hypertension,and diabetes were statistically different in the case and control group.Among 779 cases of coronary angiography positive cases,there was a significant statistical differences between age,hypertension,diabetes and coronary artery lesion counts.2)High density lipoprotein（HDL-C）,total cholesterol（TC）,low density lipoprotein（LDL-C）,triglyceride（TG）were different in the case and control group,and reached statistical significance.Among 779 cases of coronary angiography positive cases,the number of coronary artery lesions was negatively correlated with HDL-C level,and positively correlated with LDL-C level.The difference was statistically significant.However,serum TC and TG levels were not significantly correlated with coronary artery disease counts.3)Serum apolipoprotein A（ApoA）,apolipoprotein B（ApoB）,apolipoprotein E（ApoE）were different in the case and control group,and reached statistical significance.Among 779 cases of coronary angiography positive cases,the number of coronary lesions was negatively correlated with ApoA levels,and positively correlated with ApoB levels.The difference was statistically significant.However,serum ApoE levels were not significantly correlated with coronary artery lesion counts.4)There was a statistically significant difference in Homocysteine（Hcy）levels between the case and control group,and no difference was found in high sensitivity C-reactive protein（hs-CRP）levels.Among 779 cases of coronary angiography positive cases,it was found that with the increase of Hcy and hs-CRP levels,the number of coronary artery lesions also increased.Conclusion:1)age,male,systolic blood pressure,pulse pressure,FBG,smoking,drinking,diabetes,hypertension,Hcy,TG,ApoB were important risk factors for coronary heart disease.Serum HDL-C and ApoE were risk factors for coronary heart disease.2)Age,hypertension,diabetes,elevated level of serum LDL-C,ApoB,Hcy,and hs-CRP were risk factors for coronary artery lesion counts.The level of HDL-C and ApoA were negatively correlated with the number of coronary artery lesions and were protective factors for coronary artery lesion counts.