Risk Factors Of Complications In Early Stage After Transcatheter Closure Of Peri-membranous Ventricular Septal Defect

Objective: To investigate risk factors of complications in early stage after transcatheter closure of peri-membranous ventricular septal defect(pmVSD).Methods: 186 Children treated with transcatheter closure of pmVSD were admitted to this study in Children's Hospital of Chongqing Medical University form October 2015 to October 2017.After demographic data,test results and so on were recorded,participants were divided into groups basing on status of complications.Single factor analysis and multifactor logistic regression analysis were performed for risk factors of complications in early stage after transcatheter closure of pmVSD.Results: After statistical analysis,we identified lager size of pmVSD detect by transthoracic echocardiography(0R=1.264,95%CI:1.040~1.536,P=0.019)and asymmetric occluders(0R=6.732,95%CI:1.018~44.509,P=0.048)were independent risk factor of total complications,large size of pm VSD detect by transthoracic echocardiography(0R=1.577,95%CI:1.154~2.155,P=0.004)and increased right ventricular systolic pressure(0R=1.080,95%CI:1.001~1.165,P=0.047)were independent risk factors of residual shunt,increased left ventricular mean pressure(0R=1.068,95%CI:1.006~1.133,P=0.030)were protective factor of residual shunt,independent risk factor of new medium or more serious valve regurgitation was increased right ventricular systolic pressure(0R=1.068,95%CI:1.006~1.133,P=0.030)and lager size of occluders(0R=1.585,95%CI:1.003~2.506,P=0.048).Conclusions: The current study provides evidence of risk factors of total complications,residual shunt and new medium or more serious valve regurgitation in early stage after transcatheter closure of pmVSD.More research is need to assess the association between complications and hemodynamic changes,function of left heart.