The Comparison Of The Level Of T-igE And FIB In Patients With AECOPD And AECOPD With Bronchiectasia

Objective:Chronic obstructive pulmonary disease?COPD?and bronchiectasis can lead to severe pulmonary dysfunction,affect the quality of life of patients,and cause serious economic burden to society and families.However,there are relatively few related studies^[1,2,3].This study compared the general situation,hospitalization time,ICU stay,prognosis,complications and serum T-IgE,FIB levels of patients with acute exacerbation of chronic obstructive pulmonary disease complicated with bronchiectasis and those without bronchiectasis in AECOPD.It is helpful for clinicians to understand the prevalence,complications and prognosis of patients with AECOPD with bronchiectasis in this region.By analyzing the difference of the expression of serum total IgE and fibrinogen between the two groups,it can help clinicians to improve the accuracy of predicting the degree of inflammation and thrombosis or other complications,and to guide the choice of treatment programs to a certain extent.Methods:Cross-sectional study is adopted in this subject.175 patients with acute exacerbations of COPD of D group who is hospitalized in the Department respiratory medicine in Chengde Central Hospital from October 2017 toDecember 2018 were recruited in this study.And the basic informationincludeing age,gender,complications,etc.Serum T-IgE and FIB levels were measured and chest high resolution CT?HRCT?was completed.According to HRCT results,patients were divided into case group and control group:Case group was AECOPD with bronchiectasis,and control group was AECOPD without bronchiectasis.SPSS22.0 statistical software is used for dataprocessing and statistics.The measurement data conform to the normal distribution and are expressed by mean?x±s?standard deviation.Independent sample t test is used to transform the data which does notconform to the normal distribution.If it still does not conform to the normal distribution,If it still does not conform to normal distribution,it is expressed by median and quartile spacing,i.e.M?q?,using non-parametric test.And the counting data is tested by Chi square test.The set test level was 0.05,and P<0.05 was significant difference.Results:1.general informationThere were 59 patients in case group,34 males and 25 females,with an average age of?72.12±9.617?years,and 116 patients in control group,67 males and 49 females,with an average age of?72.18±10.563?years.There was no significant difference in age and sex between the two groups?P>0.05?.2.33.7%of AECOPD patients had bronchiectasis.3.ComplicationsThere were 59 cases in case group,including 10 cases with respira tory failure,0 cases with spontaneous pneumothorax and 24 cases with pulmonary heart disease.There were 116 cases in control group,includi ng 33 cases with respiratory failure,1 case with spontaneous pneumotho rax and 28 cases with pulmonary heart disease.There was no significan t difference in the incidence of respiratory failure and spontaneous pneu mothorax between the two groups?P<0.05?.The number of patients with pulmonary heart disease in the case group was higher than that in the c ontrol group?P>0.05?.4.Hospitalization and outcomeThere were 59 cases in case group,3 cases in ICU and 4 cases d ied.The median length of stay was 10.12 days.There were 116 cases in control group,8 cases in ICU and 1 case in death.The median length of stay was 9.84 days.There was no significant difference in hospitalizat ion days,ICU stay and outcome between the two groups?P>0.05?.5.Serum T-IgE and FIB levelsThe median serum T-IgE of case group was 383.95 IU/ml,and that of control group was 207.47 IU/ml.The level of T-IgE of case group was higher than that of control group.The difference was statistically significant?P<0.05?.The average level of serum FIB in case group was?6.076±1.091?g/L,while that in control group was?4.107±1.555?g/L.The level of FIB in case group was higher than that in control group.The difference was statistically significant?P<0.05?.Conclusion:1.AECOPD patients with bronchiectasis are more likely to develop pulmonary heart disease,which should be paid attention by clinicians.2.The serum T-IgE level of AECOPD with bronchiectasis was high er than that of AECOPD without bronchiectasis,suggesting that bronchi ectasis may aggravate airway inflammation in AECOPD patients,which may lay a foundation for further research and treatment options.3.The serum FIB level in AECOPD with bronchiectasis is higher t han that in AECOPD without bronchiectasis,suggesting that bronchiectas is may aggravate the hypercoagulable state of AECOPD patients and inc rease the risk of thromboembolic disease.