Clinical Study Of Fuzhengkanglao No.1 And Fuzhengkanglao No.2 Combination With The Standard Scheme Of The Global Fund Project For The Treatment Of MDR-TB

Objective:To observe several targets of multidrug resistant pulmonary tuberculosis?MDR-TB?patients before and after taking the global fund project standard regimen of anti-tuberculosis drugs,Fuzhengkanglao NO.1 or fuzhengkanglao NO.2synchronously,including mycobacterium tuberculosis sputum culture,chest CT lesion,liver function injury,blood uric acid level,body weight and TCM syndrome score.To evaluate the efficacy of Fuzhengkanglao NO.1 and fuzhengkanglao NO.2 in treatment to MDR-TB,and form a treatment scheme of Integrated Chinese and Western Medicine which is able to improve the cure rate or improvement rate of MDT-TB and reduce side effects.Methods:Retrospectively summarize the treatment results of 35 cases of MDR-TB Patients which is confirmed by the tuberculosis prevention and treatment institute,center for disease control and prevention of Zigong during 2012-2015.All patients used the global fund project standard solution 6 Z Cm Lfx?Mfx?Cs Pto/18 Z Lfx?Mfx?Cs Pto),FuzhengkanglaoNO.1 or FuzhengkanglaoNO.2 for treatment?5g each time,3times a day?,lasted for 18 months.Before the treatment,the Blood routine,liver and kidney function,acid-fast bacilli in sputum examination,chest CT,body weight and TCM syndrome score table of patients needed to be recorded,and constantly updated at the time points of the 1^st,3^rd,6 ^th,12^th and 18^th.All the data was collected by SPSS software and analyzed by self-contrast method.Results:?1?The total effective rate of fuzhengkanglaoNO.1 and fuzhengkanglao NO.2 in the Integrated Chinese and Western Medicine treatment of 35 MDR-TB patients was 62.86%,and the best situation of sputum mycobacterium tuberculosis turning negative was in the first month of treatment;?2?The total apparent efficiency of imaging was 57.14%;?3?The influence of peripheral blood leukocyte had no statistical significance;?4?For hemoglobin value,the result of contrasts between the6th and 12th month,as well as the 12th and 18th month were statistically significant;?5?For liver function,the result of a contrast between the 12th and 18 th month was statistical significance;?6?For blood uric acid,the result of contrasts between before the treatment and the 1th month,the 6 th and 12 th month were statistically significant;?7?For weight,the result of a contrast between before the treatment and the 18th month was statistical significance;?8?For TCM syndrome points,the result of contrasts between before the treatment and the 2th month as well as the2th and 18th month were statistically significant.Conclusion:The treatment programme which integrated FuzhengkanglaoNO.1 and FuzhengkanglaoNO.2,with the standard drug treatment of MDR-TB in the global fund projectis able to effectively reduce the clinical symptoms of MDR-TB patients,and has a positive efficacy after treatment.In the later stage of 18-month treatment,patients can have a increase of hemoglobin levels,fewer side effects of liver injury which is caused by standard anti-tuberculosis drugs,and maintain continuously and stablely.This programme can help patient ameliorate the emaciation symptoms,prevent the continuous weight loss,gain weight and enhance efficacy.For the hyperuricemia which is also caused by standard anti-tuberculosis drugs,through adding self-designed Tutuafulingsimiaofang water decoction to FuzhengkanglaoNO.1and FuzhengkanglaoNO.2 from the beginning of the treatment,hyperuricemia could be reduced effectively.