Dynamic Changes Of Lipoprotein-associated Phospholipase A2 In Patients With Large Arterial Atherosclerotic Cerebral Infarction And Its Correlation

Objective: To investigate the dynamic changes of Lipoprotein Associated Phospholipids A2(Lp-PLA2)in patients with large arterial atherosclerotic(LAA)and its correlation.To provide important reference and clinical basis for prevention,recurrence and prognosis of LAA.Methods:60 patients with LAA admitted in the Second Hospital of Hebei M edical University Department of Neurology were selected as case group.The Lp-PLA2 levels were detected in different periods(within 72 hour-s of onset,first month,third month,sixth month)of cerebral infarctio-n,respectively.60 physical examination without cerebral vascular history were regarded as control group.Serum Lp-PLA2 level was tested by en hanced immunoturbidimentry.Results:1.There was significant difference of Lp-PLA2 level between case group within 72 hours of onset and control group(P<0.05).The serum Lp-PLA2 level and hypertension were the risk factors of LAA(P<0.05).2.Spearman correlation analysis showed that serum Lp-PLA2 levels in patients with LAA within 72 hours of onset were positively correlated with NIHSS scores(r = 0.801,P<0.001).3.60 patients with LAA were followed up for 6 months.Among them,11 patients recurred,the other 49 patients were no recurrence group.The level of Lp-PLA2 within 72 hours of onset,and LDL in recurrence group were significantly higher than the non-recurrence(P<0.05).The Lp-PLA2 level in recurrence group was higher than that in non-recurrence group at first month,third month,and sixth month,but there was no significant difference between the two groups(P>0.05).There was no significant difference in hypertension,diabetes,alcohol consumption and smoking(P>0.05).4.The NIHSS score of patients with with LAA within 72 hours of onset was higher than that of first month,third month,and sixth month(P<0.05).There was no significant difference in first month,third month,sixth month(P>0.05).5.The level of serum Lp-PLA2 in patients with LAA within 72 hours of onset was significantly higher than that of first month,third month,and sixth month(P<0.05).Although the level of serum Lp-PLA2 in first month was also higher than that in third month and sixth month.However,there was no significant difference among serum Lp-PLA2 levels in first month,third month,sixth month(P>0.05).Conclusion:Serum Lp-PLA2 level was a risk factor of LAA.Serum Lp-PLA2 level was positively related with NIHSS score.The determination of Lp-PLA2 level was helpful for the prevention and clinical treatment of cerebral infarction.The level of serum Lp-PLA2 was significantly increased in patients with recurrent,but whether it was a predictor of recurrence of cerebral infarction should be further studied.The level of serum Lp-PLA2 in patients with LAA decreased with time and tended to stabilize.However,it was not clear when to increase,when to decrease and the degree of decline.Therefore,a higher quality study was needed to explore further.