Comprehensive Analysis Of Adverse Reactions Caused By Antibiotics In The Second Hospital Of Hebei Medical University From 2012 To 2017

Objective:By analyzing and summarizing the characteristics and related factors of adverse reactions of antibiotics reported by the second hospital of hebei medical university from January 2012 to December 2017,this study aims to attract doctors'attention to promote rational drug use in hospitals and reduce the incidence of ADR.Methods:The adverse reactions reported from January 2012 to December 2017collected by the second hospital of hebei medical university were retrospectively and descriptively analyzed by age,gender,drug classification,administration route,severity and prognosis?Microsoft Excel software was used for data processing,and the counting data were compared with the?~2 test.All P values were based on the bilateral test,and the statistical test level a was set at 0.05.Results:From 2012 to 2017,there were 334 cases of antibiotic ADR in the second hospital of hebei medical university,accounting for 34.80%of the total ADR in the second hospital of hebei medical university.The number of ADRs in female was more than that in male,there was statistical difference between male and female in all age groups,and the number of ADRs in adult group was significantly higher than that in other groups.The drugs most involved in the occurrence of adrs are cephalosporins,followed by penicillin and quinolones.The frequency of ADR in intravenous administration is the highest.The most common system of antibiotic ADR injury was skin and accessories in224 cases,followed by digestive system in 35 cases,and in the treatment of antibiotic ADR,clinicians mostly stop all suspicious drugs at the time of detection.Among the 224 cases of adverse reactions in skin and accessories,118 cases did not receive special treatment after discontinuation of the suspect drugs,64 cases of other therapeutic drugs were antihistamines,followed by 17cases of hormone combined with antihistamines,14 cases of hormone alone,and 11 cases of calcium gluconate combined with antihistamines.The ADR reporting personnel of antibiotics were mainly pharmacists.There were no deaths among all antibiotic adrs,and severe adrs accounted for 5.69%.Conclusions:1.Cefmenoxime for injection was the predominant antibiotic ADR in the second hospital of hebei medical university,accounting for 47.31%.2.The organs most frequently involved in antibiotic ADR are skin and appendages,common rashes and urticaria;Clinically,adrs for the treatment of skin and appendages should be discontinued first,and anti-allergic drugs and other symptomatic support treatments should be given at the same time.3.The adult group has the highest proportion of antibiotic ADR,but the ADR of minors and the elderly cannot be ignored;Rational and individualized administration should be achieved.such as oral administration can achieve the therapeutic purpose,intravenous administration should be avoided as far as possible,and reduce the occurrence of antibiotic ADR.4.Active reporting of adverse reactions is still seriously insufficient,and physicians should be aware of the importance of adverse reactions reporting.