Evaluation Of The Effect Of Circulating Tumor Cells On Postoperative Chemotherapy In Patients With Colorectal Cancer

Objective:Through the study of the detection of circulating tumor cells(CTC),this research aims to explore the correlation between circulating tumor cells and the clinicopathological characteristics,chemotherapy efficacy,recurrence and metastasis,and PFS of patients with stage ? colorectal cancer after radical resection with mFolfox6 regimen.Methods:From January 2012 to December 2018,32 patients with stage ? colorectal cancer who received radical resection of colorectal cancer and mFolfox6 adjuvant chemotherapy in Shanxi Dayi Hospital Affiliated to Shanxi Medical University were selected according to the inclusion and exclusion criteria and confirmed by pathological diagnosis as the study subjects.CTC was detected 1 week after surgery and 2 cycles of chemotherapy with ifish-ctc detection technique.Clinical data and CTC count of the enrolled patients were collected,and postoperative monitoring and follow-up were conducted for the patients.To analyze the correlation between CTC count,clinicopathological characteristics,chemotherapy efficacy,recurrence and metastasis,and PFS in 32 patients with stage ? colorectal cancer after radical resection with mFolfox6 adjuvant chemotherapy.Results:1.One week after radical resection,the CTC count of 32 patients with stage ?colorectal cancer was 3.69 1.99/7.5ml blood,and the positive CTC rate was 56.25%(18/32).CTC positive rate was correlated with tumor invasion depth and lymph node metastasis(P<0.05),but was not correlated with gender,age,tumor site,size,CEA,CA199,and degree of differentiation of patients(P > 0.05).2.After 2 cycles of chemotherapy,the CTC count was 2.66 1.58/7.5ml blood,and the positive CTC rate was 46.88%(15/32).After chemotherapy,the mean value of CTC decreased and the positive rate decreased,and the difference was statistically significant(P<0.05).3.At the end of the follow-up period,recurrence and metastasis occurred in 15 patients,13 in CTC positive patients and 2 in CTC negative patients.The probability of recurrence and metastasis in CTC positive patients was higher than that in negative patients.4.Compared with those whose CTC values increased after chemotherapy and those whose CTC values remained unchanged or even decreased,the PFS was shorter,and the difference was statistically significant(P<0.05).Conclusion:1.Peripheral blood CTC count was associated with tumor invasion depth and lymph node metastasis in patients with stage ? colorectal cancer.2.CTC is an independent predictor of recurrence and metastasis in patients,and the probability of recurrence and metastasis in patients with positive CTC is higher than that in patients with negative CTC.3.Peripheral blood CTC count was correlated with the efficacy of chemotherapy after radical resection for stage ? colorectal cancer patients,and affected the PFS of patients.