The Clinical Research Of Donor Selection In Haploidentical Stem Cell Transplantation With With Low-dose Anti-t-lymphocyte Globulin And And Peripheral Blood Stem Cells Source

Identifying the best donor for haploidentical stem cell transplantation(Haplo-SCT)is becoming increasingly important for clinicians as the number of haploidentical related stem cell transplantation procedures grows rapidly worldwide.An algorithm for donor selection in related HLA haplotype-mismatched transplantation has not been clearly established.We studied 8 consecutive years of outcomes for T-cell-replete(TCR)Haplo-SCT with low-dose anti-T-lymphocyte globulin(ATG)and unitary peripheral blood stem cells(PBSCs)source to identify the potential characteristics of HLA haploidentical related donors that influence transplant outcomes.We enrolled 332 hematological malignant patients who underwent Haplo-SCT with myeloablative conditioning(MAC)regimen and PBSCs source at our center from 2008 to 2016.The results of research found that patients who received transplants from donors younger than 40 years of age had lower non-relapse mortality(NRM)[hazard ratio(HR)=0.473,confidence interval(CI)95%,0.262-0.852;p=0.013]and superior overall survival(OS)(HR=0.646,CI 95%,0.439-0.951;p=0.027).However,the blood type,relationship and donor gender did not significantly affect transplantation results.Our data indicate that age is the remarkable factor associated with the outcomes of haploidentical related SCT,with low-dose ATG and PBSCs donor source for HLA haplotype-mismatched related donors.