Clinical Study On Jianpi Yangwei Ointment For Intervention Of Susceptible Population Of Cold

ObjectiveIn this study,clinical randomized controlled trials were conducted to observe the effect of the target regimen on the cold situationa and health status of the target population,and to provide evidence-based medical evidence and clinical research examples for the intervention of Jianpi Yangwei Ointment in sub-healthy people.MethodsIn this study,a randomized controlled study was conducted to enroll 120 eligible subjects,which were randomly divided into control group and experimental group,60 cases per group.The experimental group was treated with Jianpi Yangwei Ointment and lifestyle interventions.The control group was compared with lifestyle interventions for a total of 12 weeks.The subjects' cold and health status were evaluated before intervention,12 weeks after intervention,and 1 year after intervention.ResultsA total of 120 people were included in the study,of which 103 completed the intervention,and the drop-off rate was 14.3%.A total of 99 patients were followed up for 1 year after enrollment,and 4 patients were not followed up because follow-up time has not arrived yet.The subjects were mainly female,the proportion of youth and middle-aged people was roughly equal,mainly above the medium level of education.The number of colds and the severity of the cold:After the intervention,the experimental group experienced a slight decrease in the number of colds(P>0.05)with no significant difference;the VAS score decreased(P<0.01)with signigicant difference;and there was no significant shortening of the cold disease course(P>0.05).In the control group,the number of colds,VAS scores and the cold course decreased slightly(P>0.05),and there were no significant difference.Compared with the control group,there was no significant difference in the number of colds,VAS scores and cold course in the experimental group(P>0.05).One year after the intervention,compared with the pre-intervention,the number of colds in the experimental group decreased(P<0.01)the VAS score decreased(P<0.01),which were significant difference;but there was no significant shortening of the cold disease course(P>0.05).The number of colds in the control group was significantly reduced(P<0.01);the cold disease course was shorten with significant difference(P<0.01);the VAS score of the cols decreased slightly(P>0.05)with no significant difference.Compared with the control group,the number of colds in the treatment group was significantly lower than that in the control group(P<0.01).There was significant difference in the cold disease course between the experimental group and the control group(P<0.05).There was no significant difference in the VAS score and between the groups(P>0.05).In general,the overall cold situation in the experimental group improved compared with that before the intervention,and the improvement was more obvious than the control group.Quality of life:12 weeks after the intervention,the quality of life score of the treatment group increased before the intervention(P<0.05),and there was significant difference.Compared with the control group,the degree of elevation in the treatment group was significantly higher(P<0.05).Physical condition:In the subjects,the constitution was mainly yang deficiency,followed by qi deficiency and dampness-heat constitution.Jianpi Yangwei ointment had some improvement on qi deficiency and yin deficiency(P<0.05),and there were significant differences.The improvement of colds in yang-eficiency and qi-deficiency subjects is consistent with the improvement of cold in the overall subject.Safety and adverse reactions:In the experimental study,no significant abnormalities were found in laboratory indicators such as liver and kidney function and blood routine.The proportion of people with adverse reactions in the experimental group accounted for 19.2%,most of them were mild adverse reactions,and the symptoms could be alleviated or disappeared after intervention.ConclutionJianpi Yangwei Ointment is safe and effective for people with susceptibility to colds,and the number of colds,the severity of colds,the quality of life,and the bias of physical fitness have improved.Under the premise of syndrome differentiation,Jianpi Yangwei Ointment can be widely promoted to those who are susceptible to colds.However,Some people taking the oinment will have adverse reactions such as sore throat and abdominal distension.It is advisable to adjust the function of spleen and stomach with Chinese medicine in advance.