Correlation Between TCM Constitution And Classification Of Serum IL-1? And IL-6 In Patients With Atherosclerosis

ObjectiveTo explore the distribution of TCM constitution types of atherosclerosis(AS)and its relationship with serum levels of interleukin-1?(IL-1?)and interleukin-6(IL-6),so as to provide an objective theoretical basis for syndrome differentiation and treatment.Methods100 cases of atherosclerosis admitted to Guangdong Traditional Chinese Medicine Hospital from August 2018 to March 2019 were included.According to the consti tution classification rules and decision tables of TCM constitution in the Classification and.Judgment Table of TCM constitution,the TCM constitution types of patients were identified by questionnaires.Patients with mild temperament were classified as mild temperament group,patients with Qi depression,blood stasis,damp-heat and phlegm-dampness were classified as solid biased temperament group,patients with Yin deficiency,Qi deficiency and yang deficiency were classified as deficiency biased temperament group.General data of patients were collected,such as name,age,past medieal history,etc.Inflammatory indicators included serum IL-1?,IL-6,tumor necrosis factor-alpha(TNF-a),high-sensitivity C-reactive protein(hs-CRP);metabolic related indicators included fasting blood glucose,fasting insulin,total cholesterol(cholesterol).TC,total glyceride(TG),low density lipoprotein cholesterol(LDL-C).To compare the expression levels of serum IL-1? and IL-6 in different constitutional types of atherosclerosis.Results1.General situation:A total of 100 atherosclerosis patients were included in the study,of which 44(44%)were male and 56(56%)were female.The average age of the patients was 61.4+5.2 years.2.Of the 100 patients with atherosclerosis,10(10%)were of mild temperament,and 10 were of mild temperament group.There were 9 cases(9%)of Yang deficiency,10 cases(10%)of Qi deficiency,5 cases(5%)of Yin deficiency,and 24 cases(24%)of deficiency biased group.Qi depression in 3 cases(3%),phlegm and dampness in 25 cases(25%),blood stasis in 21 cases(21%),dampness and heat in 17 cases(17%)and solid biased group in 66 cases(66%).There were O cases(0%)of special quality.3.There were significant differences in serum IL-1? and IL-6 levels between the solid biased group and the deficient biased group(P<0.05),but there was no significant difference between the solid biased group and the gentle biased group(P>0.05).There were significant differences in TNF-a level between the solid biased group and the plain biased group and the deficient biased group(P<0.05).There were significant differences in hs-CRP level between the solid biased group and the plain biased group and the deficient biased group(P<0.05).4.In the comparison of metabolic factors,the level of fasting insulin in atherosclerotic solid biased group was significantly different from that in deficient biased group(P<0.05),and there was no significant difference between atherosclerotic solid biased group and placid biased group.There was no significant difference among the three groups in other commonly used metabolic factors such as fasting blood sugar and lipid composition(P>0.05).Conclusion:1.The distribution of TCM constitution in atherosclerosis patients is mainly based on the substantive biases of phlegm-dampness,blood stasis and damp-heat.2.The serum levels of IL-1?,IL-6,TNF-a,hs-CRP in patients with atherosclerosis with solid bias were higher than those in patients with deficiency bias.3.The expression level of fasting insulin in the solid biased group was higher than that in the deficient biased group.