Study On The Relationship Between The Percentage Of Erythroid Cells In The Bone Marrow And The Prognosis Of Patients With Myelodysplastic Syndrome

Objective:To investigate the effect of the percentage of erythroid cells in the bone marrow(BMERY)on prognosis in myelodysplastic syndrome.Methods:The retrospective analysis was made of 109 patients with MDS admitted to Jiangxi Provincial People's Hospital from July 2012 to August 2017.According to the degree of erythroid hyperplasia,they were divided into three groups: BMERY<15%,15% ? BMERY < 35% and BMERY ? 35%.To compare The clinical characteristics of the three groups and evaluate the prognostic significance of erythroid hyperplasia.Results:There were no significant differences in gender,age,WBC,and PLT among the three groups(p>0.05).There was a significant difference in Hb between 15% ?BMERY < 35% and BMERY?35%(p=0.032).The comparison of bone marrow image showed that the marrow blasts was not significantly different among the three groups(p=0.052),and the ratio of erythrocytes in early stage was significantly different between the BMERY<15% group and BMERY?35% group(p<0.001,p=0.004),the proportion erythrocytes in late stage was significantly different between the groups(p<0.001).Analysis of morphologic dysplasia in myelodyspla-stic syndromes showed that only erythroid dysplasia were statistically significant between the BMERY<15% group and the BMERY?35% group(p=0.002).Survival analysis showed that the median survival time of the three groups was 12 months,10.5 months,and 10 months,and the difference was not statistically significant(p>0.05).Kaplan-Meier analysis showed that marrow blast and the erythrocyte in early stage were statistically significant in the prognosis of MDS(p=0.011,p=0.032).Correlation analysis showed that BMERY was positively correlated with peripheral blood hemoglobin(correlation coefficient was 0.158,p<0.05),and there was anegative correlation with marrow blast(correlation coefficient-0.229,p=0.023).The ratio of bone marrow blast cells to survival time was negative correlation(correlation coefficient-0.229,p=0.021).Conclusion:The proportion of early normoblast and myeloblast in the bone marrow has a certain significance in judging the prognosis of MDS.In addition,the BMERY had no significant effect on the prognosis of MDS,but it was found to be positively correlated with peripheral blood hemoglobin,and was negatively correlated with the marrow blast ratio.