Observation Of Curative Effect Of TACE Combined With Apatinib Mesylate Tablets In The Treatment Of Intermediate And Advanced Stage Hepatoma

Objective:To explore the difference of curative effect between the transcather arterial chemoembolization(TACE)combined with Apatinib mesylate tablets and simple TACE in the treatment of intermediate and advanced stage hepatoma.Materials and method:The clinical data of 60 patients with intermediate and advanced stage hepatoma who received interventional treatment at the**Hospital from May 2015 to December 2015 were retrospectively analyzed.Patients were divided into observation group(n=30)and control group(n=30)according to whether combination with Apatinib or not.Indexes of serum alpha-fetoprotein(AFP),vascular endothelial growth factor(VEGF),and Matrix metalloproteinase-9(MMP-9)before and three months after the treatment of the two groups were compared.And objective remission rate,overall survival,and adverse effects rate between the two groups were also compared.Result:The difference of serum VEGF?MMP-9?AFP before treatment between the two groups were not statistically significant(P>0.05).Indexes of serum VEGF?MMP-9?AFP in the two groups at three months after treatment were all decreased(P<0.05).Indexes of serum AFP,VEGF,MMP-9 after treatment in the observation group were all lower than that in the control group(P<0.05).Objective remission rate in the observation group at 6 months after treatment was higher than that of the control group,though the difference was not statistically significant(P>0.05).Objective remission rate in the observation group at 12 months after treatment was better than that of the control group,and the difference was statistically significant(P<0.05).The 6-month,12-month,and 24-month survival rates in the observation group and control group were 93.3%,66.7%,38.6%and 83.3%,52.4%,15.0%,respectively,and median survival time were 14 months and 19 months respectively.Overall survival in the observation group was significantly better than that in the control group,and the difference was statistically significant(p<0.05).Differences of occurrence rate of fever,stomachache,nausea and vomiting,myelosuppression,diarrhea,weak,and pruritus between the two groups were not statistically significant(P>0.05).However,occurrence rate of hypertension,hand-foot syndrome,proteinuria,and rash in the observation group were higher than that in the control group,and the differences were statistically significant(P<0.05).Conclusions:Compared with simple TACE,apatinib combined with TACE can get better clinical efficacy.