Clinicla Characteristics And Risk Factors For 187 Chinese Patients With Essential Thrombocythemia

Objective :To analyze clinical and molecular characteristics of essential thrombocythemia and explore risk factors for treatment strategies.Method:A retrospective analysis was performed on 187 patients diagnosed with ET in our hospital from January 2010 to March 2019.Result:A total of 187 patients diagnosed with ET in our hospital from January 2010 to March 2019 were included in the retrospective study.RESULTS: All 187 patients with ET had a median age of onset of 64(21-96)years,79 males and 108 females.At a median follow-up time of 51(0-109)months,60 cases of severe thrombotic events occurred,including 52 cases of arterial thrombosis(86%).The main cause of arterial thrombosis was cerebral infarction.There were 111 cases(59.4%)with JAK2 V617 F mutation positive and 76 cases(40.6%)with mutation-negative patients.The WBC,PLT and age of JAK2 positive patients were significantly higher than those of negative patients(P<0.05).Binary logistic regression analysis showed that the JAK2 gene mutation(P=0.013),CVF(P=0.00),previous thrombosis history(P=0.008),age(P=0.043)were statistically significant.177 patients with ET were grouped according to the revised IPSET.The incidence of CVF thrombosis in the very low-risk group was higher than that in the non-CVF group [37.5%(6/16)versus 8.8%(3/34),p=0.02].The incidence of CVF thrombosis was higher in the high-risk group than in the nonCVF group [67.3%(35/52)versus 21.2%(7/33),p=0.00].85 patients with high-risk ET,retrospective analysis found that hydroxyurea combined with aspirin treatment of thrombosis rate higher than interferon combined with aspirin treatment [65.7%(23/35)? 31.0%(9/29),P=0.006].Conclusion:The thrombotic events in patients with ET are mainly arterial thrombosis.JAK2 gene mutations,CVF events,previous history of thrombosis,and age were independe-nt factors of ET thrombosis risk.CVF is an independent risk factor for thrombosis in Chinese patients with ET,and CVF should be added to the thrombotic stratification model.Specific stratification needs further study.