| Objective: To explore the relationship between T3 level and the severity,size and prognosis of cerebral infarction.So as to provide evidence support for the diagnosis,treatment and prognosis of patients with cerebral infarction.Methods: 200 patients with first acute cerebral infarction from September 2017 to December 2018 were selected as research objects.The age,gender,onset time,fasting blood glucose,uric acid,homocysteine and other data of the patients at admission were collected.Inquire about the patient's past medical history,such as the history of coronary heart disease,history of hypertension,history of smoking,history of diabetes,history of atrial fibrillation,etc.All patients were tested for thyroxine levels on the 2nd and 14 th day after admission.They were divided into low T3 level group and normal T3 level group according to the level of T3 level measured on the second day after admission.At the same time,the National Institutes of Health Stroke Scale was assessed on the first and 14 th days after admission,Groups were divided according to the area of cerebral infarction,In the cerebral infarction group,the modified Rankin Scale(mRS)was used to assess the post-stroke physical function after 30 days of follow-up.The NIHSS score,cerebral infarct size,mRS score and other clinical aspects were comparedbetween the low T3 level group and the normal T3 level group.compare changes in thyroid hormone levels on days 1 and 14 of the patient's admission.Results:1.Comparing the general data and related biochemical indicators in the low T3 level group and the normal T3 level group in acute cerebral infarction,The results indicated that there was no significant difference in gender,history of hypertension,smoking history,history of atrial fibrillation,history of coronary heart disease,history of hyperlipidemia,hyperuricemia,hyperhomocysteine,time of admission,T4 level at admission and TSH level at admission between low and normal T3 level groups(P > 0.05).there were statistically significant differences in age,T3 level,fasting blood glucose level and NIHSS score between the two groups(P < 0.05).2.Age,NIHSS score and fasting blood glucose on admission were used as independent variables,and the decrease in T3 level was used as the dependent variable.Logistic regression analysis showed that there were statistically significant differences between age,admission NIHSS score and the decrease in T3 level in patients with acute cerebral infarction(P < 0.05);3.There was a statistically significant difference in the extent of infarct size between the low T3 level group and the normal T3 level group(P<0.05).There was a statistically significant difference between the small-area cerebral infarction group and the large-area cerebral infarction group.Significance,the incidence of low T3 level in the small area cerebral infarction group and the middle area cerebral infarction group was statistically significant,but the incidence of low T3 level in the large area cerebral infarction group and the middle area cerebral infarction group was not statistically significant;4.There was a statistically significant difference in NIHSS scores between the low T3 level group and the normal T3 level group on the 14 th day after admission(P<0.05).There was a statistically significant difference in the incidence of ? NIHSS ? 2between the two groups(P<0.05).There was a statistically significant difference in theincidence of mRS ?1(P < 0.05);5.There was a statistically significant difference between the T3 level on day 1 and the T3 level on day 14(P<0.05).There was no significant difference in the T4 level and TSH level between the 1st and 14 th day of admission(P>0.05).Conclusions: 1.The older the patients with acute cerebral infarction,the more severe the neurological deficit,the more likely the T3 level to decrease,and the T3 level is related to the degree of neurological deficit of cerebral infarction;2.T3 levels are associated with cerebral infarct size,and moderate and large areas of cerebral infarction are more likely to reduce T3 levels.;3.T3 level is related to the prognosis of cerebral infarction.Low T3 level may represent poor prognosis of cerebral infarction,which is helpful for clinical assessment of patients' conditions;4.After treatment,patients with cerebral infarction will have elevated T3 level and no significant changes in TSH and T4 level. |
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