| Objective To explore the effects of apolipoprotein E(Apo E)gene-polymorphisms and serum cyclophilin A(Cyp A)concentration on cognitive impairment in patients with subcortical ischemic vascular disease(SIVD).Methods126 patients with SIVD from XX Hospital were enrolled.All subjects underwent head magnetic resonance imaging(MRI)to assess the severity of white matter lesions(WML)and the number of lacunar infarctions(LI).And the cognitive functions were evaluated by Montreal cognitive assessment(Mo CA),Activity of daily living scale(ADL),Hachinski ischemic score(HIS),Hamilton depression scale(HAMD).The126 patients were divided into two groups: SIVD with cognitive impairment group(SVCI)and SIVD with non-cognitive impairment(SNCI)group.Serum Cyp A concentration and Apo E gene-polymorphisms were detected in both groups.Results(1)Compared with SNCI group,Serum Cyp A concentration were significantly higher in SVCI group(P < 0.01).(2)The frequency of Apo E ? 3 / ? 4 genotype and Apo E ?4 allele were significantly higher in SVCI group(25.6 % / 20.7 %)compared with SNCI group(6.8 % / 6.8 %).Otherwise,the frequency of Apo E ? 3/? 3 genotype and Apo E ? 3 allele were lower in SVCI group(51.2 % / 70.1 %)compared with SNCI group(81.8 % / 88.6 %),the differences were statistically significant(P<0.05).(3)Serum Cyp A concentration was significantly higher in patients with Apo E ? 4 allele carrier compared with patients without Apo E ? 4 allele carrier(P < 0.01).(4)Logistic regression analysis revealed that hypertension,higher serum total cholesterol concentration,higher serum Cyp A concentration and Apo E ? 4 allele carrier could improve the onset risk of SVCI(P<0.05).Conclusion Apo E ? 4 allele carrier and increased serum Cyp A concentration may promote the occurrence and development of SVCI.Detecting serum Cyp A concentration and Apo E gene-polymorphisms may provide a theoretical basis for early diagnosing SVCI. |
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