Research On The Correlation Between Chemokines MIF,CCL23 And Acute Cerebral Infarction

BackgroundStroke is the leading cause of death and disability in China.Acute cerebral infarction(ACI)is the most common type of stroke,accounting for more than 80% of all strokes.However,the effective treatment for ACI is very simple,and it is urgent to develop a new treatment method.In recent years,foreign studies have shown that chemokines are involved in the inflammatory response of cerebral ischemia and reperfusion after ischemia in ACI,and on this basis,a variety of new immunotherapy methods have been developed.Some scholars have further studied that there is a close relationship between MIF,CCL23 and ACI,but most of them are animal model experiments.The role of them in human has not been completely clear,and further research is needed.ObjectiveThe purpose of our study is to further understand the pathophysiological processes of ACI from the perspective of neuroimmunology by in-depth discussion of the close relationship between chemokines MIF,CCL23 and ACI.At the same time explain the relativity of MIF,CCL23 and the degree of neurological deficit,prognosis and the clinical significance of them in ACI patients.To provide a new treatment idea and method to further improve the clinical treatment effect of ACI.Methods79 cases of continuous collection of ACI were experimental group,and according to TOAST standard divide into three types;In the same period,79 healthy patients who matched the age and sex of the experimental group were the control group.Measured the serum concentrations of MIF and CCL23 during admission,and determinated patients by NIHSS,Barthel indices and the modified RAKIN scale(m RS),to analyze the relationship between MIF,CCL23 and other indicators and its influencing factors.ResultsCompared with control group,the level of MIF(1317.36±275.46)pg/ml and CCL23(153.034±39.73)pg/ml is difference in experimental group(P<0.05);The MIF was positively associated with NIHSS(r=0.946,P<0.01)? m RS(r=0.773,P<0.01)?,negatively with Barthel(r=-0.671,P<0.01)?time from presentation(r =-0.233,P<0.05),but it is not related to age;The CCL23 also was positively associated with NIHSS(r=0.870,P<0.01)?m RS(r=0.730,P<0.01)?age(r=0.230,P<0.05),negatively with Barthel(r=-0.671,P<0.01)?time from presentation(r =-0.372,P<0.05),but it is not related to gender.The difference of MIF and CCL23 concentrations between different TOAST subtypes was statistically significant(P<0.001).ROC curve showed that the diagnostic value of MIF is higher than CCL23.ConclusionsMIF,CCL23 and ACI have significant correlations.MIF and CCL23 can be used as novel biomarkers for assessing the degree of neurological deficits and prognosis in patients with ACI,and may serve as novel biological targets for the treatment of ACI.This is important for reducing the lethality and disability rate of ACI.