Correlation Between Neutrophil-to-lymphocyte Ratio And Prognosis In Patients With Advanced Non-small Cell Lung Cancer

Background The incidence of lung cancer has increased year by year and has been the leading cause of death from malignant tumors.About 85% of the pathological types of lung cancer are non-small cell lung cancer(NSCLC),about 20% of whom can undergo surgery,about 56% of lung cancer patients have advanced and advanced stage of treatment,and the effective rate of advanced NSCLC chemotherapy is 21.80%-28.10 %,median survival is 11 months,showing limited benefits of chemotherapy.Synchronous chemoradiotherapy has a serious adverse reaction,but comprehensive interventional therapy is a new model with remarkable efficacy and high safety.In recent years,many studies have confirmed that chronic inflammation plays an important role in the occurrence and development of tumors,and is closely related to tumor cell proliferation,angiogenesis and metastasis,and even affects systemic therapeutic response.Objective With the deepening of research on cancer,it has been found that systemic inflammatory reactions have certain effects on body tumors.Neutrophil-to-lymphocyte ratio(NLR),which is one of the important indicators of systemic inflammatory response,is closely related to multiple tumors.The aim of this study was to investigate the association of NLR with prognosis in patients with advanced non-small cell lung cancer(NSCLC).Methods A retrospective study was performed on the clinical data of 68 patients with advanced non-small cell lung cancer who underwent interventional therapy in the Third Affiliated Hospital of Anhui Medical University.The preoperative NLR value was calculated.By establishing the ROC survival curve,NLR=3.8 was used as the demarcation point.The sensitivity and specificity were 82.4%,and the area under the curve(AUC)was 0.861,which was divided into high NLR group(NLR?).3.8)Compared with the low NLR group(NLR<3.8),the progression-free survival time and overall survival time of the two groups were compared,and the risk factors for possible prognosis were analyzed by univariate analysis.The results of univariate analysis were statistically significant.The factors were further analyzed by multivariate analysis to identify relevant risk factors that could independently influence the prognosis.Results After the intervention,the median survival time was 421 days.The median survival time was 292 days in the high NLR group and 506 days in the low NLR group.The median overall survival time of the two groups was statistically significant.The significance of learning(P<0.01);median progression-free survival time of 152 days in high NLR group and 341 days of median progression-free survival in low NLR group,the median progression-free time difference between the two groups was statistically significant(P=0.001).In the univariate analysis,the presence of distant metastasis,the number of interventional procedures <3 times and NLR ? 3.8 were the risk factors affecting the overall survival time and progression-free survival time(P<0.01);in the multivariate analysis,there was a distant place.Metastasis and NLR ?3.8 were independent risk factors for the overall survival time.The presence of distant metastasis,the number of interventional procedures <3 times and NLR?3.8 were independent risk factors for progression-free survival.Conclusion According to the study,preoperative NLR can be used as an evaluation index for interventional surgery in the treatment of patients with advanced non-small cell lung cancer.The prognosis of high NLR is poor.Since the acquisition of NLR only requires examination of blood routines,which is one of the essential items before and after the interventional follow-up,in the future clinical work,patients with advanced NSCLC can be performed according to different NLR.The distinction between the high-risk group and the low-risk group is based on timely and feasible interventional therapy to help patients achieve a better prognosis.