Study On Characteristics Of Attentional Function In Young And Middle-aged Patients With Type 2 Diabetes With Mild Cognitive Impairment

Objectives To investigate the attention function characteristics of young and middle-aged patients with type 2 diabetes mellitus with mild cognitive impairment through the attention network paradigm in the cognitive behavioral paradigm,and find out the key links affecting cognitive processing in young and middle-aged patients with type 2 diabetes.To provide new ideas and reference for the development of intervention programs for young and middle-aged patients with mild cognitive impairment in type 2 diabetes.Methods The case-control study design,from August 2017 to June 2018,80 patients with type 2 diabetes who were admitted to the endocrinology department of a grade a hospital in Anhui province and 40 people who underwent physical examination in a community in Hefei were selected as subjects.The subjects were divided into healthy control group,young and middle-aged type 2 diabetes non-mild cognitive impairment group,and young and middle-aged type 2 diabetes with mild cognitive impairment group using the Montreal Cognitive Assessment Scale,Daily Living Ability Scale,and Global Deterioration Scale.Through general situation questionnaire,Hamilton anxiety scale and Hamilton depression rating scale investigation of the patient's general condition,anxiety and depression,and using the attention network test in the cognitive behavioral paradigm to measure the attention function of three groups of people,the specific impairment components of attention function in young and middle-aged patients with type 2 diabetes mellitus with mild cognitive impairment were explored.Results(1)Young and middle-aged type 2 diabetes mild cognitive impairment group compared with healthy control group visual space / implementation [(3.43 ± 0.95)vs(4.58 ± 0.63),P < 0.001],attention [(4.93 ± 1.04)vs(5.83 ±0.38),P<0.001],language [(2.45±0.63)vs(2.98±0.15),P<0.001],abstraction [(1.18±0.78)vs(1.60±0.49),P<0.001],delayed recall [(3.00±1.19)vs(4.03±0.83),P<0.001],orientation [(5.83±0.38)vs(5.98±0.15),P=0.032] and the total score of the Montreal Cognitive Rating Scale [(23.73±1.39)vs(27.95±1.08),P<0.001] score difference was statistically significant;(2)Young and middle-aged type 2 diabetes mild cognitive impairment group compared with young and middle-aged type 2 diabetes non-mild cognitive impairment group compared with visual space / implementation [(3.43 ± 0.95)vs(4.55 ± 0.67),P < 0.001],attention [(4.93±1.04)vs(5.70±0.64),P<0.001],language [(2.45±0.63)vs(2.93±0.26),P<0.001],abstraction [(1.18±0.78)vs(1.80±0.40),P < 0.001],delayed recall [(3.00 ± 1.19)vs(4.33 ± 0.76),P < 0.001] and the total score of the Montreal Cognitive Rating Scale [(23.73 ± 1.39)vs(28.10 ± 1.03),P < 0.001],the difference was statistically significant;(3)Attention network test showed that young and middle-aged type 2 diabetes mild cognitive impairment group compared with healthy control group the correct rate [(97.87±2.57)vs(99.72±0.72),P<0.001] was lower,and attentional executive control [(116.95± 37.57)vs(44.84±29.39),P<0.001] decreased,attentional orientation [(26.58±11.70)vs(35.19±12.89),P=0.006] decreased,average response time [(682.09±112.21)vs(516.29±82.67),P < 0.001] prolonged,the difference was statistically significant;(4)Attention network test showed that the young and middle-aged type 2 diabetes mild cognitive impairment group compared with the young and middle-aged type 2 diabetes non-mild cognitive impairment group,attentional executive control [(116.95 ± 37.57)vs(94.66 ± 30.95),P < 0.001] decreased,average response time [(682.09 ± 112.21)vs(602.09 ± 88.75),P < 0.001] prolonged,the difference was statistically significant;(5)Attention network test showed that the young and middle-aged type 2 diabetes non-mild cognitive impairment group compared with the healthy control group to attentional executive control [(94.66 ± 30.95)vs(44.84 ± 29.39),P < 0.001] decreased,the average response time [(602.09 ±88.75)vs(516.29±82.67),P<0.001] prolonged,the difference was statistically significant.Conclusions(1)The cognitive impairment of patients with mild cognitive impairment in young and middle-aged with type 2 diabetes is specifically affected by visual space/execution,attention,language,abstraction,delayed recall;(2)the main impaired component of the attention function of patients with non-mild cognitive impairment in young and middle-aged type 2 diabetes is attentional execution control;(3)the main impaired component of the attention function of patients with mild cognitive impairment in young and middle-aged type 2 diabetes are attentional orientation and attentional executive control.